无创神经调控技术在慢性顽固性疼痛中的应用及进展  

Application and progress of non-invasive neuromodulation techniques in chronic refractory pain

作　　者：彭婷婷 何微微 苟晨 李晓敏 王晓明[1] Peng Tingting;He Weiwei;Gou Chen;Li Xiaomin;Wang Xiaoming(Department of Neurology,Affiliated Hospital of North Sichuan Medical College,Institute of Neurological Diseases of North Sichuan Medical College,Nanchong,Sichuan 637000,China)

机构地区：[1]川北医学院附属医院神经内科,川北医学院神经疾病研究所,四川南充637000

出　　处：《中华神经科杂志》2021年第6期626-630,共5页Chinese Journal of Neurology

基　　金：南充市脑功能修复与调控重点实验室建设项目(NCKL201906)。

摘　　要：慢性顽固性疼痛是一种由多种原因引起、易反复发作、对多种药物治疗疗效差甚至无效、患者难以忍受的疼痛,其影响着全球超过10%的人口,给社会及经济造成巨大负担。随着神经科学的发展,神经调控技术越来越受到学者们的关注,给慢性顽固性疼痛治疗带来了新的方向。文中就重复经颅磁刺激(rTMS)、经颅直流电刺激(tDCS)、经颅聚焦超声刺激(tFUS)、光遗传学等无创神经调控技术在慢性顽固性疼痛方面的研究及进展进行综述。Chronic refractory pain is an excruciating pain caused by various reasons,which is easily recurrent and barely responded to multiple drugs.It affects more than 10%of the global population and thus causes a huge burden on the society and the economy.With the development of neuroscience,neuromodulation technologies have been well concerned,which guide a novel direction in the treatment of chronic refractory pain.This review summarizes the research progresses on repetitive transcranial magnetic stimulation,transcranial direct current stimulation,transcranial focused ultrasound stimulation,optogenetics and other non-invasive neuromodulations in the treatment of chronic refractory pain.

关 键 词：慢性疼痛 顽固性 无创 经颅磁刺激 经颅直流电刺激 光遗传学 

分 类 号：R402[医药卫生—临床医学]