血必净联合西医疗法治疗急性胰腺炎疗效的Meta分析  

Meta-analysis on the Efficacy of Xuebijing Combined with Western Medicine Therapy in the Treatment of Acute Pancreatitis

作　　者：徐思思 李芳斓 康建媛[2] 李海文 郭绍举[1] XU Sisi;LI Fanglan;KANG Jianyuan;LI Haiwen;GUO Shaoju(The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen 518033,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院,广东深圳518033

出　　处：《云南中医学院学报》2021年第1期30-41,共12页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：广东省中医药局面上科研项目(20191272)。

摘　　要：目的 系统评价血必净联合西医疗法治疗急性胰腺炎的疗效。方法检索中国知网、万方、维普、Pubmed、Cochrane Library、Web of science、Embase数据库中关于血必净联合西医疗法对比西医疗法治疗急性胰腺炎的随机对照试验,时间从建库至2021年1月,按纳入和排除标准进行筛选,提取数据后使用Revman 5.3软件进行Meta分析。结果共纳入61项研究,4868例患者。Meta分析结果显示血必净联合西医疗法治疗急性胰腺炎较单用西医疗法的总有效率更高[RR=1.20,95%CI(1.17,1.24)],腹痛缓解时间[MD=-1.64,95%CI(-1.87,-1.40)]、腹胀缓解时间[MD=-1.48,95%CI(-1.78,-1.18)]、住院时间[MD=-4.84,95%CI(-6.78,-2.90)]更短,降低血淀粉酶[MD=-112.45,95%CI(-152.24,-72.67)]、白细胞[MD=-2.44,95%CI(-3.13,-1.76)]、CRP[SMD=-2.12,95%CI(-2.51,-1.72)]、IL-6[SMD=-2.11,95%CI(-2.54,-1.69)]、IL-8[SMD=-1.98,95%CI(-2.57,-1.40)]、TNF-α[SMD=-2.06,95%CI(-2.43,-1.68)]的作用更强,差异均具有统计学意义。结论血必净联合西医疗法治疗急性胰腺炎疗效良好,值得推广。由于纳入研究的样本量小、文献质量低、异质性高、存在发表偏倚,结论仍需进一步验证。Objective To systematically evaluate the efficacy of Xuebijing combined with western medicine therapy in the treatment of acute pancreatitis.Methods Randomized controlled trials of Xuebijing combined with western medicine therapy versus western medicine therapy in the treatment of acute pancreatitis from CNKI,Wanfang,VIP,Pubmed,Cochrane Library,Web of Science and Embase databases were searched from the time of establishment to January 2021.Screening was conducted according to the inclusion and exclusion criteria,and Meta-analysis was conducted using Revman 5.3 software after data extraction.Results A total of 61 studies and 4868 patients were included.The results of Meta-analysis showed that Xuebijing combined with western medicine therapy in the treatment of acute pancreatitis had a higher total effective rate[RR=1.20,95%CI(1.17,1.24)],shorter time to relieve abdominal pain[MD=-1.64,95%CI(-1.87,-1.40)]and abdominal distension[MD=-1.48,95%CI(-1.78,-1.18)],and shorter hospitalization time[MD=-4.84,95%CI(-6.78,-2.90)]than western medicine alone.The effect of decreasing blood amylase[MD=-112.45,95%CI(-152.24,-72.67)],white blood cells[MD=-2.44,95%CI(-3.13,-1.76)],CRP[SMD=-2.12,95%CI(-2.51,-1.72)],IL-6[SMD=-2.11,95%CI(-2.54,-1.69)],IL-8[SMD=-1.98,95%CI(-2.57,-1.40)],TNF-α[SMD=-2.06,95%CI(-2.43,-1.68)]was stronger.Conclusion Xuebijing combined with western medicine therapy in the treatment of acute pancreatitis has a good effect and is worth popularizing.However,due to the small sample size,low literature quality,high heterogeneity and publication bias,the conclusions still need to be further verified.

关 键 词：血必净 西医疗法 急性胰腺炎 META分析 

分 类 号：R259[医药卫生—中西医结合]