人体包虫病免疫学诊断研究进展  

Advances in immunological diagnosis research of human hydatid disease

作　　者：肖玲 字金荣 吴方伟[1] 李奔福[1] 彭佳[1] XIAO Ling;ZI Jin-rong;WU Fang-wei;LI Beng-fu;PENG Jia(Yunnan Institute of Parasitic Diseases Control and Prevention,Pu'er,Yunnan 665000,China;Kunming Medical University College of Public Health,Kunming,Yunnan 650500,China)

机构地区：[1]云南省寄生虫病防治所,云南普洱665000 [2]昆明医科大学公共卫生学院,云南昆明650500

出　　处：《中国热带医学》2021年第6期600-606,共7页China Tropical Medicine

摘　　要：包虫病(Echinococcosis)是由细粒棘球绦虫(E.granulosus)、多房棘球绦虫(E.multiloculari)、石渠棘球绦虫(E.shiquicus)、少节棘球绦虫(E.orligarthrus)和福氏棘球绦虫(E.vogeli)引起的人兽共患寄生虫病。严重危害人体健康,给患者及其家庭带来极大痛苦和沉重的经济负担,是导致我国西部农牧区群众因病致贫、因病返贫的主要原因之一,也是一个严重的世界性公共卫生问题。包虫病的免疫学诊断对于临床的诊治、手术及预后效果评价和现场流行病学调查起到重要作用,目前包虫病常用的免疫学检测方法有ELISA、DIGFA、IHA等,其敏感性、特异性和准确性各有高低,在实验条件、操作简易性、耗时、现场流调、临床应用及检测结果可提供的信息等方面也有所差异。因目前常用的免疫学检测方法缺乏标准化,且结果受包虫囊肿活性、大小等因素的影响,灵敏度和特异度均不理想。本文就包虫病患者的免疫学诊断研究近况进行综述。以指导包虫病防治中的免疫学检测研究和实际应用。Echinococcosis is a zoonotic parasitic disease caused by E. granulosus, E. multiloculari, E. shiquicus, E.orligarthrus and E.vogeli. Hydatid disease seriously endangers human health, brings great pain and heavy economic burden to the patients and their families, and is one of the main reasons for the poor people in the agricultural and pastoral areas in western China, and is a serious worldwide public health problem. Immunological diagnosis of hydatid disease plays an important role in clinical diagnosis, operation and prognosis evaluation and field epidemiological investigation. At present, the commonly used immunological detection methods for hydatidosis include ELISA, DIGFA, IHA, etc, with their own advantages and disadvantages, sensitivity, specificity and accuracy, and differences in experimental conditions, operation simplicity, time,field flow regulation, clinical application and information provided by test results. Due to the lack of standardization of the commonly used immunological detection methods, and the influence of the activity and size of hydatid cyst and other factors,the sensitivity and specificity are not ideal. This paper mainly introduces the research progress of hydatid immunology diagnosis at home and abroad to guide the practical application of hydatid prevention and treatment.

关 键 词：包虫病 免疫学 酶联免疫吸附试验 固相免疫金银法 间接红细胞凝集试验 免疫印迹试验 诊断 

分 类 号：R521.1[医药卫生—内科学]