前列舒通及坦索罗辛联合用药对前列腺增生患者术后功能恢复的干预研究  

Intervention effect of combination of Qianlie Shutong and Tamsulosin on postoperative functional recovery in patients with benign prostatic hyperplasia

作　　者：黄克岭[1] 于艳辉[1] 高双友[1] HUANG Ke-ling;YU Yan-hui;GAO Shuang-you(Department of Uropoiesis Surgery,Kailuan General Hospital,Tangshan 063000,China)

机构地区：[1]开滦总医院泌尿外科,河北唐山063000

出　　处：《实用药物与临床》2021年第6期525-530,共6页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨前列舒通及坦索罗辛联合用药对良性前列腺增生症(BPH)术后患者尿动力学、预后相关因子表达的影响。方法前瞻性选取我院2018年1月至2019年12月BPH患者141例,依据就诊顺序编号,采用电脑随机数字表按照1∶1∶1配对原则随机分为3组,各47例。术后均给予常规处理,对照组A术后3 d加用前列舒通,对照组B术后3 d加用坦索罗辛,观察组术后3 d给予前列舒通+坦索罗辛治疗,对比三组术前、术后3个月各项指标的变化情况。结果术后3个月观察组国际前列腺症状评分(IPSS)、储尿期症状评分(IPSS-S)、排尿期症状评分(IPSS-V)、最大排尿压力(Pves)、最大逼尿肌压力(Pdet)、最大尿道压力(Pmax)等指标均得到明显改善,且改善程度大于对照组A、B,差异有统计学意义(P<0.05);术后3个月三组TNF-α、NGF、TGF-β、PSA均较术前降低,且观察组降低程度大于对照组A、B,差异有统计学意义(P<0.05);术后3个月观察组BPHQLS评分大于对照组,差异有统计学意义(P<0.05)。观察组总不良反应发生率为13.04%,与对照组A、B的10.87%、15.22%比较,差异无统计学意义(P>0.05)。结论BPH术后患者采用前列舒通及坦索罗辛联合用药能进一步改善患者尿动力学,调节血清因子,促进患者术后症状改善及病情恢复。Objective To investigate the effect of the combination of Qianlie Shutong and Tamsulosin on the expression of urodynamic and prognostic factors in patients with benign prostatic hyperplasia(BPH)after surgery.Methods From January 2018 to December 2019,141 patients with BPH in our hospital were prospectively selected.According to the serial number of treatment,the computer random number table was adopted to randomly divide them into 3 groups according to the 1∶1∶1 matching principle,47 cases in each group.Routine treatments were given after the operation.The control group A was treated with Qianlie Shutong at 3 days after the operation,the control group B was treated with Tamsulosin at 3 days after the operation,and the observation group was treated with Qianlie Shutong+Tamsulosin 3 days after the operation.The changes in the indexes were compared among the three groups before and at 3 months after surgery.Results The international prostate symptom score(IPSS),international prostatic symptom storage sub score(IPSS-S),international prostatic symptom score-voiding(IPSS-V)score,maximum urine flow rate(Qmax),bladder residual urine volume(RU),maximum urination pressure(Pves),maximum detrusor pressure(Pdet),maximum urethral pressure(Pmax)and other indicators of the observation group were significantly improved after 3 months,and the degree in improvement was greater than that of the control group A and B(P<0.05).At three months after operation,TNF-α,NGF,TGF-βand PSA in the three groups were all lower than those before operation,and the degree of reduction in the observation group was greater than that of the control group A and B(P<0.05).The BPHQLS score of the observation group was higher than that of the control group at 3 months after operation(P<0.05).The total incidence of adverse events in the observation group was 13.04%,and compared with 10.87%and 15.22%in the control group A and B,the difference was not statistically significant(P>0.05).Conclusion The combined administration of Qianlie Shutong and Tamsulos

关 键 词：前列腺增生 前列舒通 尿动力学 转化生长因子 坦索罗辛 性激素 

分 类 号：R699.8[医药卫生—泌尿科学]