基于脑电信号的耳鸣患者静息态频谱图及注意力研究  

An electroencephalogram-based study of resting-state spectrogram and attention in tinnitus patients

作　　者：黄海云 蔡跃新[2] 冯学技 李远清[1,3] HUANG Haiyun;CAI Yuexin;FENG Xueji;LI Yuanqing(School of Automation Science and Engineering,South China University of Technology,Guangzhou 510000,P.R.China;Department of Otolaryngology Head and Neck Surgery,Sun Yat-sen University,Guangzhou 510520,P.R.China;Brain Computer Intelligence Research Center,Pazhou Lab,Guangzhou 510330,P.R.China)

机构地区：[1]华南理工大学自动化科学与工程学院,广州510000 [2]中山大学孙逸仙纪念医院耳鼻咽喉头颈外科,广州510520 [3]脑机智能研究中心,人工智能与数字经济广东省实验室,广州510330

出　　处：《生物医学工程学杂志》2021年第3期492-497,共6页Journal of Biomedical Engineering

基　　金：广东省重点研发计划(2018B030339001);国家自然科学基金(61633010);国家重点研发计划(2017YFB1002505)。

摘　　要：耳鸣的发病率较高,会影响患者的注意力、情绪、睡眠等,甚至会造成严重心理障碍以及自杀倾向。当前并没有统一客观的检测及治疗手法,且耳鸣的发病机制尚不明确。本文采集了耳鸣患者和健康被试的静息态脑电(EEG),对比两组数据在δ(0.5~3 Hz)、θ(4~7 Hz)、α(8~13 Hz)、β(14~30 Hz)以及γ(31~50 Hz)频带的功率谱拓扑图的差异,以此探讨耳鸣的神经机制。共招募了16名耳鸣患者和16名健康被试参加试验。静息态实验结果发现,耳鸣患者静息态频谱能量在所关注的全部频带上都高于健康被试,利用t检验得到有统计学意义的差异区域主要集中在θ和α频带右颞叶,以及β和γ频带的左右颞叶、前额和顶叶区域。另外,本文还设计了任务态的注意力实验,进一步研究耳鸣对注意力的影响。结果显示,耳鸣患者注意力任务的分类准确率显著低于健康被试,最高值分别为80.21%和88.75%,提示耳鸣可能导致了患者的注意力衰弱。The incidence of tinnitus is very high,which can affect the patient’s attention,emotion and sleep,and even cause serious psychological distress and suicidal tendency.Currently,there is no uniform and objective method for tinnitus detection and therapy,and the mechanism of tinnitus is still unclear.In this study,we first collected the resting state electroencephalogram(EEG)data of tinnitus patients and healthy subjects.Then the power spectrum topology diagrams were compared of in the band ofδ(0.5–3 Hz),θ(4–7 Hz),α(8–13 Hz),β(14–30 Hz)andγ(31–50 Hz)to explore the central mechanism of tinnitus.A total of 16 tinnitus patients and 16 healthy subjects were recruited to participate in the experiment.The results of resting state EEG experiments found that the spectrum power value of tinnitus patients was higher than that of healthy subjects in all concerned frequency bands.The t-test results showed that the significant difference areas were mainly concentrated in the right temporal lobe of theθandαband,and the temporal lobe,parietal lobe and forehead area of theβandγband.In addition,we designed an attention-related task experiment to further study the relationship between tinnitus and attention.The results showed that the classification accuracy of tinnitus patients was significantly lower than that of healthy subjects,and the highest classification accuracies were 80.21%and 88.75%,respectively.The experimental results indicate that tinnitus may cause the decrease of patients’attention.

关 键 词：耳鸣 静息态 频谱分析 脑电图 注意力 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]