超声背散射零差K成像监测微波消融  

Monitoring microwave ablation using ultrasound backscatter homodyned K imaging:Comparison of estimators

作　　者：宋爽[1,2] 张英华 周著黄[1,2] 吴水才[1,2] SONG Shuang;ZHANG Yinghua;ZHOU Zhuhuang;WU Shuicai(Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,P.R.China;Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation,Beijing 100124,P.R.China;Beijing You'an Hospital,Capital Medical University,Beijing 100069,P.R.China)

机构地区：[1]北京工业大学环境与生命学部,北京100124 [2]智能化生理测量与临床转化北京市国际科研合作基地,北京100124 [3]首都医科大学附属北京佑安医院,北京100069

出　　处：《生物医学工程学杂志》2021年第3期520-527,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金项目(61871005,11804013);北京工业大学环境与生命学部人才培养创新基金项目。

摘　　要：研究超声背散射零差K模型参数成像(简称零差K成像)监测微波消融凝固区的可行性,对比2种最新的零差K模型参数估算方法,即RSK法(基于信号包络振幅的信噪比、偏度和峰度的方法)和XU法(基于信号强度的一阶矩、X统计量和U统计量的方法)。首先,将离体猪肝微波消融实验中采集的超声背散射信号经噪声辅助互相关算法、包络检测、滑动窗口法、数字扫描变换和颜色映射等操作得到零差K成像。然后利用20例离体猪肝微波消融实验来评估零差K成像监测凝固区的效果。结果显示RSK法和XU法的受试者工作特征曲线下面积平均值±标准差分别为0.77±0.06、0.83±0.08。RSK法和XU法监测凝固区的精度平均值±标准差分别为(86±10)%和(90±8)%。XU法估算凝固区面积值与实际猪肝组织凝固区面积的Bland-Altman一致性强于RSK法。XU法参数估算并成像所耗时间少于RSK法。研究显示超声背散射零差K成像可用于监测微波消融过程中凝固区的变化,XU法优于RSK法。The feasibility of ultrasound backscatter homodyned K model parametric imaging(termed homodyned K imaging)to monitor coagulation zone during microwave ablation was investigated.Two recent estimators for the homodyned K model parameter,RSK(the estimation method based on the signal-to-noise ratio,the skewness,and the kurtosis of the amplitude envelope of ultrasound)and XU(the estimation method based on the first moment of the intensity of ultrasound,X statistics and U statistics),were compared.Firstly,the ultrasound backscattered signals during the microwave ablation of porcine liver ex vivo were processed by the noise-assisted correlation algorithm,envelope detection,sliding window method,digital scan conversion and color mapping to obtain homodyned K imaging.Then20 porcine livers’microwave ablation experiments ex vivo were used to evaluate the effect of homodyned K imaging in monitoring the coagulation zone.The results showed that the area under the receiver operating characteristic curve of the RSK method was 0.77±0.06(mean±standard deviation),and that of the XU method was 0.83±0.08(mean±standard deviation).The accuracy to monitor the coagulation zone was(86±10)%(mean±standard deviation)by the RSK method and(90±8)%(mean±standard deviation)by the XU method.Compared with the RSK method,the Bland-Altman consistency for the coagulation zone estimated by the XU method and that of actual porcine liver tissue was higher.The time for parameter estimation and imaging by the XU method was less than that by the RSK method.We conclude that ultrasound backscatter homodyned K imaging can be used to monitor coagulation zones during microwave ablation,and the XU method is better than the RSK method.

关 键 词：超声 背散射 零差K分布 微波消融 监测 

分 类 号：R445.1[医药卫生—影像医学与核医学]