多室软包装输液袋压裂过程模拟的有限元方法  

Finite element method simulating bursting process of multi-chamber flexible package infusion bag

作　　者：岳怀俊 王冠石 蒋文涛 谭鸿波 刘文军 朱仲强 朱麟 YUE Huaijun;WANG Guanshi;JIANG Wentao;TAN Hongbo;LIU Wenjun;ZHU Zhongqiang;ZHU Lin(Department of Mechanics&Engineering,College of Architecture and Environment,Sichuan University,Chengdu 610065,P.R.China;Failure Mechanics and Engineering Disaster Prevention and Mitigation Key Laboratory of Sichuan Province,Chengdu 610065,P.R.China;Sichuan Kelun Pharmaceutical Co.Ltd,Chengdu 610500,P.R.China)

机构地区：[1]四川大学建筑与环境学院力学科学与工程系,成都610065 [2]破坏力学与工程防灾减灾四川省重点实验室,成都610065 [3]四川科伦药业股份有限公司,成都610500

出　　处：《生物医学工程学杂志》2021年第3期556-562,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金项目(11972239)。

摘　　要：本文针对以实验方式研究多室输液袋构型和工艺存在的低效率、高成本及多参数研究难以开展的问题,提出采用基于流体腔的有限元方法模拟多室输液袋在外载荷下的受力及变形过程。研究建立了不同尺寸下的输液袋曲面模型,采用ABAQUS中的流体腔方法模拟输液袋在压裂实验条件下的流固耦合变形过程。以弱焊剥离实验获取的弱焊剥离应力作为数值模拟的破裂准则,提取破裂时的压裂力与压裂实验结果进行对比,并分析所得应力分布是否满足压裂实验弱焊破裂过程。结果表明:考虑由样品弱焊差异及偏心压裂等因素引起的实验误差,基于流体腔的有限元方法能够准确地模拟输液袋受力及变形过程。本文方法可用于输液袋构型及工艺改进研究,降低研究成本,提升研究效率。This study aims to overcome the shortcomings such as low efficiency,high cost and difficult to carry out multi-parameter research,which limited the optimization of infusion bag configuration and manufacture technique by experiment method.We put forward a fluid cavity based finite element method,and it could be used to simulate the stress distribution and deformation process of infusion bag under external load.In this paper,numerical models of infusion bag with different sizes was built,and the fluid-solid coupling deformation process was calculated using the fluid cavity method in software ABAQUS subject to the same boundary conditions with the burst test.The peeling strength which was obtained from the peeling adhesion test was used as failure criterion.The calculated resultant force which makes the computed peeling stress reach the peeling strength was compared with experiment data,and the stress distribution was analyzed compared with the rupture process of burst test.The results showed that considering the errors caused by the difference of weak welding and eccentric load,the flow cavity based finite element method can accurately model the stress distribution and deformation process of infusion bag.It could be useful for the optimization of multi chamber infusion bag configuration and manufacture technique,leading to cost reduction and study efficiency improvement.

关 键 词：多室输液袋 流体腔 有限元 弱焊强度 

分 类 号：TQ460.69[化学工程—制药化工]