补气通络胶囊辅助治疗糖尿病周围神经病变疗效及对血清中MDA、T-AOC、SOD水平的影响  

The Effect of Buqi Tongluo Capsule on Diabetic Peripheral Neuropathy and the Levels of MDA,T-AOC and SOD in Serum

作　　者：黄楚燕 杨棣华[1] 梁宏宇[2] HUANG Chuyan;YANG Dihua;LIANG Hongyu(Department of Pharmacy,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Department of Cardiology,Guangdong Second Hospital of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学第一附属医院药学部,广东广州510405 [2]广东省第二中医院心血管科,广东广州510405

出　　处：《中药新药与临床药理》2021年第5期722-726,共5页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广东省中医药管理局项目(20211123)。

摘　　要：目的探讨补气通络胶囊辅助治疗糖尿病周围神经病变(DPN)的疗效及对血清丙二醛(MDA)、总抗氧化能力(T-AOC)和超氧化物歧化酶(SOD)水平的影响。方法选择2018年3月至2020年3月广州中医药大学第一附属医院收治的100例DPN患者,按随机数字表法分为观察组与对照组,每组各50例。对照组给予肌肉注射甲钴胺注射液治疗,观察组在对照组的基础上服用补气通络胶囊治疗,疗程均为4周。比较2组患者治疗前后多伦多临床评分系统(TCSS)评分、神经病变主觉症状问卷(NSS)评分、正中神经和腓总神经的神经传导速度、氧化应激指标(MDA、T-AOC和SOD)的变化情况及补气通络胶囊辅助治疗的临床疗效和安全性。结果治疗后,观察组总有效率为90.00%(45/50),对照组总有效率为72.00%(36/50),观察组总有效率明显高于对照组(P<0.05)。治疗后,2组患者的TCSS评分和NSS评分均较治疗前显著降低(P<0.05),且观察组的TCSS评分和NSS评分低于对照组(P<0.05)。2组患者治疗后的正中神经和腓总神经的感觉神经传导速度(SCV)和运动神经传导速度(MCV)较治疗前提高(P<0.05),且观察组的正中神经和腓总神经的MCV和SCV高于对照组(P<0.05)。治疗后,2组患者血清MDA水平均较治疗前降低(P<0.05),T-AOC和SOD水平较均治疗前升高(P<0.05),且观察组降低血清MDA水平和升高T-AOC及SOD水平的效果均优于对照组(P<0.05)。结论补气通络胶囊辅助治疗DPN患者疗效良好,可明显减轻患者病情严重程度,改善神经传导速度和氧化应激水平。Objective To explore the therapeutic effect of Buqi Tongluo capsule on diabetic peripheral neuropathy(DPN)and its influence on the levels of MDA,T-AOC and SOD.Methods100 DPN patients in the First Affiliated Hospital of Guangzhou University of Chinese Medicine were selected and divided into observation group(50 cases)and control group(50 cases),from March 2018 to March 2020.The control group was treated with mecobalamin injection and the observation group was treated with Buqi Tongluo capsule on the basis of the control group.The course of treatment in both groups was 4 weeks.The Toronto clinical scoring system(TCSS)score,neuropathy subjective symptom questionnaire(NSS)score,nerve conduction velocity of median nerve and common peroneal nerve,and changes of oxidative stress index(MDA,T-AOC and SOD)before and after treatment were compared between the two groups.ResultsAfter treatment,the total effective rate of the observation group was90.00%(45/50),and that of the control group was 72.00%(36/50),the total effective rate of observation group was higher than that of control group(P<0.05).The TCSS and NSS scores of two groups after treatment were lower than those before treatment(P<0.05),and the TCSS and NSS scores of observation group were lower than those of control group(P<0.05).Meanwhile,the sensory nerve conduction velocity(SCV)and motor nerve conduction velocity(MCV)of median nerve and common peroneal nerve in two groups after treatment were higher than before treatment(P<0.05),and the MCV and SCV of median nerve and common peroneal nerve in the observation group were higher than those in the control group(P<0.05).After treatment,the serum MDA level of the two groups were lower than that before treatment(P<0.05),the T-AOC and SOD levels were higher than those before treatment(P<0.05),and the effect of reducing the serum MDA level and increasing the T-AOC and SOD levels of the observation group was better than that of the control group(P<0.05).Conclusion Buqi Tongluocapsule has a good curative effect in the adjuv

关 键 词：补气通络胶囊 糖尿病周围神经病变 疗效 丙二醛 总抗氧能力 超氧化物歧化酶 

分 类 号：R285.6[医药卫生—中药学]