基于数据挖掘方法分析曹志群治疗慢性萎缩性胃炎的用药规律  

Analysis of the Medication Rule of Cao Zhiqun in the Treatment of Chronic Atrophic Gastritis Based on Data Mining

作　　者：战俊邑 张新[2] 丁楠 高慧[1] 严如根 赵玉洁 曹志群[1,2] ZHANJunyi;ZHANG Xin;DING Nan;GAO Hui;YAN Rugen;ZHAO Yujie;CAO Zhiqun(Shandong University of Traditional Chinese Medicine,Jinan 250014 Shandong,China;The Affiliated Hospital of Shandong University of Chinese Medicine,Jinan 250014 Shandong,China;Shandong Provincial Hospital,Shandong University,Jinan 250021 Shandong,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学附属医院,山东济南250014 [3]山东第一医科大学附属省立医院,山东济南250021

出　　处：《中药新药与临床药理》2021年第5期733-738,共6页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金青年科学基金项目(81904128);山东省自然科学基金项目(ZR201702190076);山东省中医药发展计划项目(2019-0101,2019-0102)。

摘　　要：目的探讨曹志群教授治疗慢性萎缩性胃炎(CAG)的用药规律。方法收集曹志群教授2016年11月至2020年1月治疗CAG的门诊病案,筛选、整理后建立数据库。使用Microsoft Excel 2019进行药物频数及性味归经分析,利用IBM SPSS 23.0软件进行因子分析和系统聚类分析。结果根据纳入、排除标准共收集处方191首,涉及中药162味。高频药物有砂仁、半夏、炒白术、丹参、党参、黄芪、枳壳、香附等;药物功效以补虚、理气、化湿为主;药性以温性为主,药味以苦、辛、甘为主,归经以脾、胃经为主;因子分析共提取公因子7个;系统聚类分析得到新处方5首。结论曹志群教授围绕CAG"中焦虚损"的基本病机,治疗从脾、胃出发,以补虚祛实、虚实兼顾为治疗准则,重视补益脾胃,同时注意调节脏腑气机升降,辅以运脾化湿、行气活血、消食化积等治法。Objective To explore the medication rule of professor Cao Zhiqun in the diagnosis and treatment of chronic atrophic gastritis(CAG).MethodsThe outpatient records of professor Cao Zhiqun in the treatment of CAG from November 2016 to January 2020 were collected,screened and sorted out to establish a database.Analysis of the frequency,four natures and five flavors,and meridians of Traditional Chinese medicine was performed by Microsoft Excel 2019,and IBM SPSS 23.0 software was used for factor analysis and systematic cluster analysis.ResultsA total of 191 effective prescriptions were included,involving 162 traditional Chinese medicines according to the inclusion and exclusion criteria.High-frequency traditional Chinese medicines are Amomi Fructus,Pinelliae Rhizoma,Atractylodis Macrocephalae Rhizoma,Salviae Miltiorrhizae Radix et Rhizoma,Codonopsis Radix,Astragali Radix,Aurantii Fructus,Cyperi Rhizoma,etc.The efficacy of traditional Chinese medicines was mainly to tonifying deficiency,regulating qi and reducing dampness.Statistics showed that the four natures of medicines are mainly warm,and the five flavors are mostly bitter,pungent and sweet.Spleen and stomach meridians are the two main channels.7 common factors were extracted by factor analysis.5 new prescriptions were obtained by systematic cluster analysis.ConclusionProfessor Cao Zhiqun takes the insufficient of Zhong Jiao as the main pathogenesis in the treatment of CAG.Starting from the spleen and stomach and following the principles of tonifying deficiency and removing excess and giving consideration to both deficiency and excess,the main treatment of CAG is to pay attention to tonifying the spleen and stomach,regulating qi machine.It is usually combined with the treatment of transporting spleen and resolving dampness,promoting qi and activating blood circulation,digestion and alleviating accumulation,etc.

关 键 词：慢性萎缩性胃炎 因子分析 聚类分析 数据挖掘 用药规律 补益脾胃 运脾化湿 行气活血 消食化积 

分 类 号：R285.6[医药卫生—中药学]