苯基联咪唑类双酰胺杀虫剂的合成与生物活性  

Synthesis and Biological Activity of Phenylbiimidazole Diamide Insecticide

作　　者：孙朋威 张泽 李焕功 李玉新[1] 郜力 李正名[1] SUN Peng-wei;ZHANG Ze;LI Huan-gong;LI Yu-xin;GAO Li;LI Zheng-ming(State Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071,China)

机构地区：[1]南开大学元素有机化学国家重点实验室,天津300071

出　　处：《农药》2021年第6期395-400,共6页Agrochemicals

基　　金：国家自然科学基金(Nos.3197228721602118)。

摘　　要：[目的]为了探索新型绿色鱼尼丁受体(RyR)类杀虫剂,设计并合成了一系列含有苯基联咪唑结构的新型双酰胺类杀虫剂。[方法]将缩合剂HATU(2-(7-偶氮苯并三氮唑)-N,N,N′,N′-四甲基脲六氟磷酸酯)应用于双酰胺类杀虫剂的合成过程中,通过其介导的酰胺缩合反应合成了系列新的结构,这是对双酰胺类杀虫剂合成研究方法的重要补充。[结果]生物学活性结果表明:在测试质量浓度下,该系列化合物中的大多数对东方黏虫(Mythimna separata)和小菜蛾(Plutella xylostella Linnaeus)具有有效的杀虫活性。[Aims]This study aims to develop novel green insecticides targeting at the ryanodine receptor(RyR),a series of novel diamide derivatives containing phenylimidole structures were designed and synthesized.[Methods]The condensing agent HATU(2-(7-azabenzotri-azol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate)was applied to the synthesis of diamide compounds and obtained a series of novel structures,which could be regarded as an important supplement to the synthetic research methods of diamide insecticides.[Results]The preliminarily biological activity tests indicated that most of these compounds showed effective insecticidal activities towards oriental armyworm(Mythimna separata)and diamondback moth(Plutella xylostella Linnaeus)at the tested concentration.

关 键 词：鱼尼丁受体 苯基联咪唑 HATU 双酰胺类杀虫剂 

分 类 号：TQ460.3[化学工程—制药化工]