流感疫苗保护效果的影响因素研究进展  

Research progress on factors influencing the protective effects of influenza vaccines

作　　者：舒跃龙 文思敏 SHU Yuelong;WEN Simin(School of Public Health(Shenzhen),Sun Yat-sen University,Shenzhen 518107,Guangdong,China)

机构地区：[1]中山大学公共卫生学院(深圳),广东深圳518107

出　　处：《山东大学学报（医学版）》2021年第5期1-7,共7页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金(82041043)。

摘　　要：每年接种流感疫苗是预防流感的最佳方法,然而当前使用的流感疫苗对人群的保护作用并不理想,这主要是由流感病毒的变异造成的。此外,流感疫苗的保护效果还受到包括遗传因素在内的许多其他因素的影响,而充分识别这些相关因素则具有重要意义。本文从疫苗与流行毒株的匹配度、疫苗因素及宿主因素等方面概括了可能影响流感疫苗保护效果的因素,并提出未来新型流感疫苗的发展方向。Annual vaccination is the best prevention of influenza.However,the protective effects of influenza vaccines currently used are poor due to variation of influenza viruses.The protective effects can also be affected by other factors including the genetic factor,and it is important to fully identify these related factors.In this paper,we briefly summarized the factors that may influence the protective effects of influenza vaccines from the aspects of the matching degree of circulating strains and vaccine strains,vaccine factors and host factors,and proposed the development direction of new influenza vaccines in the future.

关 键 词：流感疫苗 保护效果 疫苗因素 宿主因素 

分 类 号：R186[医药卫生—流行病学]