EB病毒对胃癌表观遗传学的影响  

Impact of EBV on the epigenetics of gastric carcinoma

作　　者：罗兵[1] LUO Bing(Department of Pathogen Biology,School of Basic Medical Sciences,Qingdao University,Qingdao 266071,Shandong,China)

机构地区：[1]青岛大学基础医学院病原生物学系,山东青岛266071

出　　处：《山东大学学报（医学版）》2021年第5期30-39,共10页Journal of Shandong University:Health Sciences

摘　　要：EB病毒(EBV)是一种重要的人类肿瘤病毒,与多种肿瘤的发生密切相关,其中包括约10%的胃癌。EBV在胃癌发生发展中的作用日益受到重视,被认为是除幽门螺杆菌外的另一个致病因素。EBV相关胃癌(EBVaGC)的一个重要特征是病毒和宿主基因组的广泛甲基化,仅表达有限的病毒基因,如EBV核抗原1、EBV编码的小RNA、Bam HI-A右转录本、潜伏膜蛋白2A和miRNAs。宿主细胞中与肿瘤相关的基因也受到广泛的影响。EBV感染是EBVaGC发生的重要表观遗传驱动因素。本综述讨论了EBV对EBVaGC宿主表观遗传学改变的影响及其在肿瘤发生过程中的作用。Epstein-Barr virus(EBV),an important human tumor virus,is closely related to the occurrence of a variety of tumors,including 10%gastric cancer.The role of EBV in gastric carcinogenesis has received increasing attention and EBV is considered to be another pathogenic factor in addition to Helicobacter pylori.In EBV-associated gastric carcinoma(EBVaGC),a typical characteristic is the extensive methylation of viral and host genomes,which expresses a limited number of viral genes including EBV nuclear antigen 1,EBV encoded small RNAs,Bam HI-A rightward transcripts,latent membrane protein 2 A and miRNAs.Combined with other epigenetic mechanisms,EBV infection acts as an epigenetic driver of EBVaGC oncogenesis.This review will discuss the impact of EBV on the epigenetic alterations in EBVaGC and its role in oncogenesis.

关 键 词：DNA甲基化 EB病毒 表观遗传学 胃癌 MICRORNA 

分 类 号：R373.9[医药卫生—病原生物学]