自闭症患儿肠道菌群变化及其与自闭症分级的关系  

Relationship between intestinal flora and autism grade in children with autism

作　　者：成霞 袁伯稳[1] CHENG Xia;YUAN Bo-wen(Department of Pediatrics,Haian People′s Hospital,Haian,Jiangsu 226611,China)

机构地区：[1]海安人民医院儿科,江苏226611

出　　处：《中国微生态学杂志》2021年第5期560-563,共4页Chinese Journal of Microecology

摘　　要：目的分析自闭症患儿肠道菌群的变化及其与疾病发展的关系。方法选择2018年6月至2019年6月我院收治的134例自闭症患儿为观察组,根据美国精神疾病分类与诊断标准(第5版)将自闭症患儿按病情严重程度分为一级组(51例)、二级组(47例)、三级组(36例)。选择同期于我院进行体检的50例健康儿童为对照组。比较各组儿童胃肠道症状和肠道菌群分布情况,采用Spearman相关性分析自闭症患儿病情分级与肠道菌群关系。结果对照组、一级组、二级组、三级组儿童胃肠道症状发生率依次上升(均P<0.05)。对照组、一级组、二级组、三级组儿童肠道双歧杆菌数量依次下降,而梭状芽孢杆菌、大肠埃希菌、拟杆菌、志贺菌数量依次上升(均P<0.05)。自闭症患儿肠道双歧杆菌数量与自闭症分级呈负相关(r=-0.746,P<0.001),梭状芽孢杆菌、大肠埃希菌、拟杆菌、志贺菌数量与自闭症分级呈正相关(r=0.811、0.659、0.744、0.760,均P<0.001)。结论自闭症患儿胃肠道疾病发生率较高,自闭症分级与肠道菌群分布情况具有显著相关性。Objective To investigate the relationship between intestinal flora and autism grade in children with autism. Methods A total of 134 children with autism(observation group) and 50 healthy children(control group) in our hospital from June 2018 to June 2019 were enrolled;the observation group was further divided into three subgroups according to Diagnostic and Statistical Manual of Mental Disorders-5 th Edition(DSM-5), first grade group(n=51), second grade group(n=47) and third grade group(n=36). The gastrointestinal symptoms and distribution of intestinal flora were compared among the groups. The relationship between the disease grade and intestinal flora was analyzed by using Spearman correlation. Results There was an increasing trend in the incidence of gastrointestinal symptoms among control group, first grade group, second grade group and third grade group(all P<0.05). There was a decreasing trend in intestinal Bifidobacterium count and increasing trend in intestinal Clostridium, Escherichia coli, Bacteroides and Shigella counts among control group, first grade group, second grade group and third grade group(all P<0.05). The autism grade was negatively correlated with the count of intestinal Bifidobacteria(r=-0.746,P<0.001), and positively correlated with the counts of intestinal Clostridium, Escherichia coli, Bacteroides and Shigella(r=0.811, r=0.659, r=0.744, r=0.760,all P<0.001). Conclusion The incidence of gastrointestinal symptoms is high in children with autism, and the grade of autism is significantly related to the distribution of intestinal flora.

关 键 词：自闭症 肠道菌群 差异性 相关性 

分 类 号：R72[医药卫生—儿科]