90锶-90钇敷贴在耳部瘢痕疙瘩术后患者中的应用效果  

Analysis of the Effect of 90 Strontium-90 Yttrium Application in Adjuvant Treatment of Ear Keloids

作　　者：张凤真 刘阳[1] 周涛[1] ZHANG Fengzhen;LIU Yang;ZHOU Tao(Department of Nuclear Medicine,Shangqiu First People's Hospital)

机构地区：[1]商丘市第一人民医院核医学科,476000

出　　处：《长治医学院学报》2021年第3期200-203,207,共5页Journal of Changzhi Medical College

摘　　要：目的:探讨耳部瘢痕疙瘩术后采用90锶-90钇敷贴联合复方倍他米松注射液皮下注射的临床效果。方法:分析85例耳部瘢痕疙瘩行内核切除手术治疗患者的临床资料,按其术后治疗方案不同分组。对照组42例,采用复方倍他米松注射液皮下注射治疗;观察组43例,在对照组基础上予以90锶-90钇敷贴治疗。比较2组总有效率、治疗前后瘢痕严重程度(VSS评分)、症状(红斑、硬结、瘙痒)积分、局部组织基质金属蛋白酶-1(MMP-1)、基质金属蛋白酶抑制剂-1(TIMP-1)、I型前胶原肽(PINP)表达、治疗期间不良反应情况、治疗后6个月、1年复发率。结果:观察组总有效率(95.35%)高于对照组(66.67%),差异有统计学意义(P<0.05);治疗后观察组VSS评分[(1.58±0.69)vs(2.77±0.81)分]、症状积分[(1.73±0.80)vs(2.91±0.94)分]低于对照组(P<0.05),观察组MMP-1[(20.88±2.54)vs(29.24±2.91)ng·mL^(-1)]、TIMP-1[(32.43±3.16)vs(42.74±3.78)ng·mL^(-1)]、PINP[(7.30±1.57)vs(8.94±1.80)ng·mL^(-1)]水平低于对照组,差异有统计学意义(P<0.05);2组不良反应发生率和治疗后6个月、1年复发率比较差异均无统计学意义(P>0.05)。结论:手术切除耳部瘢痕疙瘩后采用90锶-90钇敷贴联合复方倍他米松注射液皮下注射可有效促进患者瘢痕减退。Objective: To investigate the clinical effect of 90 strontium-90 yttrium application combined with compound betamethasone injection subcutaneously and surgical resection in the treatment of ear keloids. Methods: The clinical dataA total of 85 patients with ear keloids undergoing keratoectomy were analyzed and divided into study group(n=43) and control group(n=42) according to their postoperative treatment plan. All of them were treated by kernel excision. The control group received subcutaneous injection of compound betamethasone injection, and the study group received 90 strontium-90 yttrium application on the basis of the control group. The total effective rate, scar severity(VSS score), symptoms(erythema, induration, pruritus) scores, local tissue matrix metalloproteinase-1(MMP-1), tissue inhibitor of metalloprotease-1(TIMP-1) and type Ⅰ procollagen propeptide(PINP) expression before and after treatment, adverse reactions during treatment, and recurrence rate at 6 months and 1 year after treatment were compared between the two groups. Results: The total effective rate of the study group was 95.35%, which was higher than 66.67% of the control group(P<0.05). After treatment, the VSS scores and symptom scores of the two groups decreased. The scores of the study group were(1.58±0.69) and(1.73±0.80) respectively, which were lower than the(2.77±0.81) and(2.91±0.94) points of the control group(P<0.05). After treatment, the expression levels of MMP-1, TIMP-1, and PINP decreased in the two groups. The expression levels of the study group, which were lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). There was no significant difference in the recurrence rate between the two groups at 6 months and 1 year after treatment(P>0.05). Conclusion: After surgical removal of ear keloids, the use of 90 strontium-90 yttrium application combined with compound betamethasone injection subcutaneously can effectively promote the r

关 键 词：耳部瘢痕疙瘩 内核切除手术 90锶-90钇 复方倍他米松 瘢痕改善 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]