环金属铱催化2-氨基苄醇与仲醇的氢转移反应高效合成喹啉类衍生物  

Highly efficient synthesis of quinoline derivatives by hydrogen transfer reaction of 2-aminobenzyl alcohol with secondary alcohol catalyzed by cyclometalated iridium

作　　者：税红灵 钟瑜红 温慧玲[1] 罗年华 SHUI Hong-ling;ZHONG Yu-hong;WEN Hui-ling;LUO Nian-hua(School of Pharmacy,Gannan Medical University,Ganzhou 341000,China)

机构地区：[1]赣南医学院药学院,江西赣州341000

出　　处：《化学研究与应用》2021年第6期1088-1097,共10页Chemical Research and Application

基　　金：江西省教育厅项目(GJJ180801)资助;江西省科技厅项目(20161BAB213059)资助;赣南医学院校启动金项目(QD201816)资助。

摘　　要：在100℃下,以环金属铱TC-6为催化剂,KOH为碱,水为溶剂,2-氨基苄醇1与苯乙醇2发生氢转移反应,高收率(高达95%)、高选择性(>99∶1)地合成了一系列喹啉类化合物3。其结构经1 HNMR、13 CNMR和MS确证。依据前期研究及根据相关文献,提出了可能的反应机理。A series of quinolines 3 were synthesized by the hydrogen transfer reaction of 2-aminobenzyl alcohol 1 with phenylethanol 2 in high yield(up to 95%)and high selectivity(>99∶1)using iridium TC-6 as catalyst,KOH as base,water as solvent at 100℃.The structures of compounds obtained were confirmed by 1 HNMR,13 CNMR and MS.According to the previous research and the related literature,the possible reaction mechanism was proposed.

关 键 词：铱 氢转移反应 喹啉 2-氨基苄醇 仲醇 

分 类 号：O626.3[理学—有机化学]