1-硝基-4-芳基-3-丁烯酮类化合物的合成方法研究  

Study on synthesis method of 1-nitro-4-aryl-but-3-en-2-one compounds

作　　者：尹彦冰[1] 辛兆崧 王宇萌 杨杭 YIN Yan-bing;XIN Zhao-song;WANG Yu-meng;YANG Hang(Department of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006

出　　处：《化学研究与应用》2021年第6期1197-1200,共4页Chemical Research and Application

基　　金：黑龙江省自然科学基金项目(QC2016016)资助;黑龙江省教育厅基本业务专项理工面上项目(135509107)资助。

摘　　要：4-芳基取代丁烯酮类化合物可用于合成香料、电镀、杀虫驱虫等方面,因其结构特性还可作为药物合成的中间体。本文通过α-硝化的二硫缩烯酮与芳醛在碱的催化下发生缩合反应,并脱去硫环,得到一系列1-硝基-4-芳基-3-丁烯酮类化合物。本文利用新的合成方法向4-芳基取代丁烯酮的1-位引入了硝基,使该碳原子具有更强的活性,该类化合物目前鲜有报道,在有机合成方向将会有很大的研究空间。这种方法反应条件容易控制,产率极高,提纯方法简便。4-Arylbutenone compounds can be used in the synthesis of perfumes,electroplating,insecticides and insect repellents,etc.They can also be used as intermediates in pharmaceutical synthesis because of their structural characteristics.A series of 1-nitro-4-aryl-but-3-en-2-one were obtained by the condensation reaction ofα-nitrodithioketenone with aromatic aldehydes before the extraction of sulfur ring under alkaline condition.In this paper,a new synthetic method was used to introduce a nitro group to the 1-position of 4-arylbutenone,thus theα-carbon got more reaction activity.There was few reports of such compounds,and would be a lot of research space in the direction of organic synthesis.It was a synthetic method with easy controlled reaction conditions,extremely high yield,and simple purification method.

关 键 词：α-硝基二硫缩烯酮 芳香醛 缩合 1-硝基-4-芳基-3-丁烯酮 

分 类 号：O621.3[理学—有机化学]