氯吡格雷联合曲美他嗪对冠心病合并心力衰竭患者的疗效  

Effect of clopidogrel combined with trimetazidine in patients with coronary heart disease and heart failure

作　　者：尹晓东 张刚 刘日辉 张秋英[2] YIN Xiaodong;ZHANG Gang;LIU Rihui;ZHANG Qiuying(Department of Cardiology,Liaoyang Central Hospital,Liaoyang 111000,China;Department of Cardiology,the 4th Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China)

机构地区：[1]辽阳市中心医院心内科,辽阳111000 [2]辽宁中医药大学附属第四医院心内科,沈阳110000

出　　处：《西北药学杂志》2021年第3期463-466,共4页Northwest Pharmaceutical Journal

基　　金：辽宁省教育厅科学研究项目(编号:L201702)。

摘　　要：目的探究氯吡格雷联合曲美他嗪对冠心病合并心力衰竭患者心功能、血清血红素加氧酶-1(HO-1)和一氧化碳水平的影响。方法选取冠心病合并心力衰竭患者120例,均分为对照组和观察组,每组60例。对照组进行常规治疗,观察组患者在对照组治疗的基础上给予氯吡格雷联合曲美他嗪治疗,比较2组患者的治疗效果、心功能、血清HO-1、一氧化碳、血脂水平及不良反应。结果与对照组相比,观察组患者的治疗有效率显著提高(P<0.05);治疗后,2组患者的左心房内径(LAD)、右心室内径(RVD)、左心室舒张末期容积(LVEDV)和左心室射血分数(LVEF)指标均显著提升,且观察组患者的LVEF高于对照组,LAD、RVD和LVEDV低于对照组;观察组的HO-1水平低于对照组,一氧化碳高于对照组,差异均有统计学意义(P<0.05);观察组的三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)低于对照组,高密度脂蛋白(HDL)高于对照组;2组不良反应比较差异无统计学意义(P>0.05)。结论氯吡格雷联合曲美他嗪治疗冠心病合并心力衰竭患者通过改善患者的血清HO-1和一氧化碳水平,效果显著。Objective To study the effect of clopidogrel combined with trimetazidine on cardiac function,serum heme oxygenase-1(HO-1)and carbon monoxide in patients with coronary heart disease and heart failure.Methods 120 patients with coronary heart disease and heart failure were randomly divided into observation group and control group,60 patients in each group.The control group were treated with routine treatment.On this basis,patients in the observation group were treated with clopidogrel combined with trimetazidine.The treatment effect,cardiac function,serum HO-1,carbon monoxide,lipid and adverse reactions were compared.Results Compared with the control group,the treatment effective rate of the observation group was significantly improved(P<0.05);after treatment,the indexes of left atrial diameter(LAD),right ventricular diameter(RVD),left ventricular end diastolic volume(LVEDV)and left ventricular ejection fraction(LVEF)of the 2 groups were significantly improved,and the LVEF index of the observation group was significantly higher than that of the control group,and the LAD,RVD and LVEDV were lower than those of the control group;HO-1 level of the observation group was lower than that of the control group,carbon monoxide was higher than that of the control group,the differences were statistically significant(P<0.05);triglyceride(TG),total cholesterol(TC)level,low density lipoprotein(LDL)of the observation group were lower than those of the control group,high density lipoprotein(HDL)was higher than that of the control group;there was no significant difference in adverse reactions between the 2 groups(P>0.05).Conclusion Clopidogrel combined with trimetazidine in the treatment of patients with coronary heart disease and heart failure,through improving the serum HO-1 and carbon monoxide levels,the effect is significant.

关 键 词：冠心病 心力衰竭 血红素加氧酶-1(HO-1) 一氧化碳 心功能 

分 类 号：R972[医药卫生—药品]