平阳霉素注射治疗咽喉部血管瘤的临床效果探析  

The Clinical Effect of Pingyangmycin Injection in the Treatment of Pharyngeal Hemangioma

作　　者：韩纪林 HAN Jilin(Department of Pharmacy,Laiwu Central Hospital,Xinwen Mining Group,Jinan,Shandong Province,271103 China)

机构地区：[1]新汶矿业集团莱芜中心医院药剂科,山东济南271103

出　　处：《系统医学》2021年第7期161-163,共3页Systems Medicine

摘　　要：目的分析平阳霉素注射治疗咽喉部血管瘤的应用价值。方法该研究主体为2018年1月—2019年11月间来院治疗的49例咽喉部血管瘤患者。以抽签法为基准,A组25例行平阳霉素注射治疗,B组24例行地塞米松注射治疗,对比整体疗效。结果 A组的总有效率为96.00%,B组为70.83%,差异有统计学意义(χ^(2)=5.677,P=0.017)。治疗后,A组的社会功能评分为(80.69±6.33)分,B组为(72.30±6.24)分,差异有统计学意义(t=4.670,P<0.001);A组的物质生活评分为(82.36±5.49)分,B组为(75.44±5.38)分,差异有统计学意义(t=4.454,P<0.001);A组的心理功能评分为(70.36±4.69)分,B组为(65.19±4.51)分,差异有统计学意义(t=3.931,P<0.001);A组的躯体功能评分为(78.22±5.08)分,B组为(72.06±5.01)分,差异有统计学意义(t=4.272,P<0.001);A组的生活质量总分为(311.63±5.46)分,B组为(284.99±4.93)分,差异有统计学意义(t=17.902,P<0.001)。A组的不良反应率为8.00%,B组为33.33%,差异有统计学意义(χ^(2)=4.838,P=0.028)。随访6个月,A组的复发率为0.00%,B组复发率为16.67%,差异有统计学意义(χ^(2)=4.537,P=0.033)。结论为咽喉部血管瘤患者注射平阳霉素可提升疗效,减少用药不良反应,且能优化患者的生活质量,远期疗效较佳。Objective To analyze the application value of pingyangmycin injection in the treatment of pharyngeal hemangioma.Methods The subject of this study was 49 patients with throat hemangioma who came to the hospital for treatment from January 2018 to November 2019.Based on the lottery method,25 patients in group A were treated with pingyangmycin injection,and 24 patients in group B were treated with dexamethasone injection.The overall efficacy was compared.Results The total effective rate of group A was 96.00%,and that of group B was 70.83%,the difference was statistically significant(χ^(2)=5.677,P=0.017).After treatment,the social function score of group A was(80.69±6.33)points,group B was(72.30±6.24)points,the difference was statistically significant(t=4.670,P<0.001);the material life score of group A was(82.36±5.49)points,Group B scored(75.44±5.38)points,the difference was statistically significant(t=4.454,P<0.001);group A’s mental function score was(70.36±4.69)points,group B was(65.19±4.51)points,the difference was statistically significant(t=3.931,P<0.001);the physical function score of group A was(78.22±5.08)points,group B was(72.06±5.01)points,the difference was statistically significant(t=4.272,P<0.001);the total quality of life score of group A was(311.63±5.46)points,Group B had(284.99±4.93)points,the difference was statistically significant(t=17.902,P<0.001).The adverse reaction rate of group A was 8.00%,group B was 33.33%,the difference was statistically significant(χ^(2)=4.838,P=0.028).After 6 months of follow-up,the recurrence rate of group A was 0.00%and that of group B was 16.67%,the difference was statistically significant(χ^(2)=4.537,P=0.033).Conclusion Injecting pingyangmycin into patients with pharyngeal hemangioma can improve the curative effect,reduce adverse drug reactions,and can optimize the quality of life of the patients,and the long-term curative effect is better.

关 键 词：平阳霉素 注射治疗 咽喉部血管瘤 不良反应 临床疗效 

分 类 号：R4[医药卫生—临床医学]