sICAM-1和IL-36在儿童支原体肺炎中的临床研究  

The clinical study of sICAM-1 and IL-36 in children with mycoplasma pneumoniae pneumonia

作　　者：李丹[1] 高淑青[2] 曲艳杰[2] 王冬梅[2] LI Dan;GAO Shuqing;QU Yanjie;WANG Dongmei(Baotou Medical College,Baotou 014060,China;Department of Paediatrics,Baotou Fourth Hospital)

机构地区：[1]包头医学院,内蒙古包头014060 [2]包头市第四医院

出　　处：《包头医学院学报》2021年第5期25-28,共4页Journal of Baotou Medical College

摘　　要：目的:分析sICAM-1和IL-36在儿童肺炎支原体肺炎(mycoplasma pneumoniae pneumonia,MPP)中的表达水平及两者在肺炎支原体肺炎中的临床意义。方法:根据第八版《诸福棠实用儿科学》社区获得性肺炎(community-acquired pneumonia,CAP)的诊断标准,选取2019年3月至2020年1月于内蒙古包头市第四医院儿科确诊为肺炎的患儿66例,根据MPP的诊断标准分为MPP组(28例),非MPP对照组(38例),选取同期支气管异物儿童16例为正常对照组,采用ELISA法测定肺泡灌洗液中可溶性细胞间粘附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)和白介素(interleukin-36,IL-36)的水平,用ROC曲线评价IL-36、sICAM-1对MPP的诊断效能。结果:MPP组sICAM-1和IL-36表达水平高于非MPP组(P<0.05)及正常对照组(P<0.05)。非MPP组sICAM-1和IL-36表达水平高于正常对照组(P<0.05),sICAM-1诊断肺炎支原体肺炎的AUC为0.818(95%可信区间为0.703-0.902),其敏感度为71.43%,特异度为84.21%;IL-36对诊断MPP的AUC为0.875(95%可信区间为0.770-0.944),其敏感度为75.00%,特异度为89.47%。结论:检测sICAM-1和IL-36在MPP中表达水平有助于MPP患儿的临床诊断。Objective:To analyze the levels of expression and clinical significance of sICAM-1 and IL-36 among children with mycoplasma pneumoniae pneumonia(MPP).Methods:According to the diagnostic criteria of MPP and CAP in the eighth edition of Zhufutang Practical Pediatrics,a total of 66 children with pneumonia in paediatric department of Baotou Fourth Hospital were selected and divided into MPP group(28 children)and non-MPP group(38 children).Sixteen children with bronchial foreign bodies in the same period were selected as the normal control group.ELISA was used to detect the levels of sICAM-1and IL-36 in alveolar lavage fluid(BALF),and the receiver operating characteristic(ROC)curve was used to evaluate the diagnosis efficiency for MPP.Results:sICAM-1 and IL-36 expression levels in MPP group were higher than those in non-MPP group(P<0.05)and normal control group(P<0.05).sICAM-1 and IL-36 expression levels in the non-MPP group were higher than those in the normal control group(P<0.05).The area under ROC curve of sICAM-1 was 0.818(95%CI 0.703-0.902),and the sensitivity and specificity of the sICAM-1 were 71.43%and 84.21%.The area under ROC curve of IL-36 was 0.875(95%CI 0.770-0.944),and the sensitivity and specificity of the IL-36 were 75.00%and 89.47%.Conclusion:The detection of sICAM-1 and IL-36 expression levels in MPP is helpful for the clinical diagnosis of children with MPP.

关 键 词：肺炎支原体肺炎 肺泡灌洗液 SICAM-1 IL-36 儿童 

分 类 号：R725.6[医药卫生—儿科]