外源性胆汁酸对畜禽抗热应激作用研究进展  

Research Progress on Effects of Exogenous Bile Acids on Heat Stress in Livestock and Poultry

作　　者：尹畅 吴维达[1] 曹爱智 张宏福[1] YIN Chang;WU Weida;CAO Aizhi;ZHANG Hongfu(State Key Laboratory of Animal Nutrition,Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China;Shandong Longchang Animal Health Care Co.,Ltd.,Jin’an 251100,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,动物营养学国家重点实验室,北京100193 [2]山东龙昌动物保健品有限公司,济南251100

出　　处：《动物营养学报》2021年第6期3081-3090,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：十三五国家重点研发计划项目(2016YFD05005)。

摘　　要：胆汁酸作为胆汁的重要成分,在促进营养吸收、保障畜禽健康方面具有重要作用。胆汁酸通过非受体介导途径与极性磷脂分子结合乳化脂类以促进脂类和脂溶性物质吸收,作为关键的信号分子激活特异受体和细胞信号通路,促进糖和脂肪代谢稳态,保护肠道屏障和抗应激损伤。近年来,外源性胆汁酸对缓解热应激导致的负面影响,诸如胰岛素抵抗、脂肪堆积、肠道屏障受损、氧化应激等作用逐渐受到关注。本文系统地对胆汁酸代谢进行了综述,详细总结了胆汁酸对机体的调控机制,以期对外源性胆汁酸缓解生长阶段猪和肉鸡热应激的理论研究与应用提供参考。As an important component of bile,bile acid plays an important role in promoting nutrient absorption and protecting the health of livestock and poultry.It combines emulsified lipids with polar phospholipid molecules through a non-receptor-mediated pathway to promote the absorption of lipids and fat-soluble substances.It also acts as a key signal molecule to activate specific receptors and cell signaling pathways to not only promote glucose and lipid metabolism,but also protect against the intestine barrier dysfunction and oxidative stress.In recent years,the roles of exogenous bile acids on alleviating the negative states of heat stress,such as insulin resistance,fat accumulation,intestinal barrier dysfunction,and oxidative stress,have gradually attracted attention.This article systematically described the metabolism of bile acids,summarized in detail the regulation mechanism of bile acids on the body,and provided references for the theoretical research and application of exogenous bile acids to relieve heat stress in growing pigs and broilers.

关 键 词：热应激 畜禽 胆汁酸 健康 

分 类 号：S811.2[农业科学—畜牧学]