阿司匹林与肝素治疗复发性流产与血栓前状态的远期疗效  

Long-term Observation of Recurrent Abortion and Prethrombotic Status by Using Aspirin and Heparin

作　　者：邱敏玲[1] 邱洁玲 王玲 李维真[1] QIU Min-Ling;QIU Jie-Ling;WANG Ling;LI Wei-Zhen(Department of Obstetrics and Gynecology,Sadhu Maternal and Child Health Hospital(Huzhong Hospital),Guangzhou 510800,China)

机构地区：[1]广州市花都区妇幼保健院(胡忠医院)妇产科,广州510800

出　　处：《中国药物经济学》2021年第5期100-103,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨阿司匹林与肝素治疗复发性流产与血栓前状态的远期疗效。方法选取2017年9月至2020年9月广州市花都区妇幼保健院妇产科收治的复发性流产与血栓前状态患者300例作为研究对象,根据随机数字表法分为观察组和对照组,各150例。对照组给予阿司匹林,观察组在对照组基础上采用腹壁皮下注射低分子肝素治疗。比较两组血栓前状态指标、性激素水平变化、妊娠并发症、妊娠结局以及不良反应发生情况。结果治疗后,观察组血栓前状态指标D-二聚体(D-D)显著降低且明显低于对照组(P<0.05),凝血酶时间(TT)显著升高,且明显高于对照组(P<0.05);观察组激素水平明显高于对照组(P<0.05);观察组妊娠成功率(89.34%)明显高于对照组(74.00%),同时妊娠并发症发生率(10.00%)明显低于对照组(22.67%),差异有统计学意义(P<0.05),而两组不良反应发生率比较差异无统计学意义(P>0.05)。结论肝素联合阿司匹林能够有效治疗复发性流产与血栓前状态患者,调节激素水平,降低妊娠并发症的发生,改善妊娠结局,安全性较好。Objective To explore the status of recurrent abortion and thrombus in the long term by using aspirin and heparin.Methods A total of 300 patients with recurrent abortion and pre-thrombotic status admitted to the Department of Obstetrics and Gynecology of Sadhu Maternal and Child Health Hospital from September 2017 to September 2020 were selected as the research objects and were divided into an observation group and a control group,with 150 cases in each group,according to the principle of random number table.The control group was given aspirin and the observation group was treated with low-molecular-weight heparin subcutaneously injected into the abdominal wall plus aspirin.Pre-thrombotic status indicators,sex hormone levels,pregnancy complications,pregnancy outcomes and adverse reactions of the 2 groups were compared.Results After treatment,the pre-thrombotic status index d-dimer(D-D)in the observation group was significantly decreased and significantly lower than that in the control group(All P<0.05),and thrombin time(TT)was significantly increased and significantly higher than that in the control group(P<0.05).The hormone level of the observation group was significantly higher than that of the control group(P<0.05).The pregnancy success rate(89.34%)in the observation group was significantly higher than that in the control group(74.00%),and the incidence of pregnancy complications(10.00%)was significantly lower than that in the control group(22.67%),with statistically significant differences(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Heparin combined with aspirin can effectively treat patients with recurrent abortion and pre-thrombotic status,improve their immune function,regulate hormone levels,reduce the incidence of pregnancy complications,improve pregnancy outcomes,with good safety.

关 键 词：复发性流产 血栓前状态 阿司匹林 肝素 

分 类 号：R714.21[医药卫生—妇产科学] R984[医药卫生—临床医学]