SAA、CRP及呼吸道病原体谱IgM检测在呼吸道感染性疾病的诊断价值  

The diagnostic value of SAA,CRP and respiratory pathogen spectrum IgM detection in respiratory infectious diseases

作　　者：冯钧静 黄莺琴 钟信球 薛国平 梁嘉琪 温展鹏 FENG Jun-jing;HUANG Ying-qin;ZHONG Xin-qiu(Clinical lab of the Seventh People's Hospital of Nanhai district,Foshan 528427,China)

机构地区：[1]佛山市南海区第七人民医院检验科,广东佛山528247

出　　处：《中国处方药》2021年第6期191-192,共2页Journal of China Prescription Drug

基　　金：佛山市自筹经费科技计划项目(1920001001335)。

摘　　要：目的分析血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)及呼吸道病原体谱IgM检测在呼吸道感染性疾病的诊断价值。方法选取2020年1月~2020年5月65例呼吸道感染性疾病患者作为研究对象,检测血清中SAA、CRP、呼吸道病原体谱IgM的水平。结果65例标本中,IgM阳性30例,占46.15%。病原体检出率由高至低分别为甲型流感病毒15例、肺炎支原体14例、乙型流感病毒11例、嗜肺军团菌7例、腺病毒1例、副流感病毒1例、肺炎衣原体0例、呼吸道合胞病毒0例。65例标本中,混合感染10例,两种病原体感染最为常见,占60.00%(6/10),多为肺炎支原体及甲型流感病毒感染,占30.00%。三种病原体感染在混合感染中占40%(4/10),其中肺炎支原体、甲型流感病毒及乙型流感病毒感染最为常见,占20%(2/10)。去除混合性感染中细菌和病毒感染10例,对其余55例按照细菌组、病毒组、阴性组进行分类,比较呼吸道感染病原体种类与SAA、CRP之间的关系。细菌组CRP阳性率高于病毒组,病毒组CRP高于阴性组。细菌组和病毒组SAA阳性率均为100%,均高于阴性组。差异具有统计学意义(P<0.05)。结论呼吸道病原体谱IgM检测提供快速准确的诊断依据,CRP反映早期细菌感染,敏感性不高。SAA反映早期细菌和病毒感染,敏感度高。三者结合有助于快速识别病原体,使呼吸道感染性疾病患者得到正确及时的治疗。Objective To analyze the diagnostic value of serum amyloid protein A(SAA),C-reactive protein(CRP),and respiratory pathogen spectrum IgM detection in respiratory infectious diseases.Methods 65 patients with respiratory infectious diseases in our hospital from January 2020 to May 2020 were selected as the research subjects,and the levels of SAA,CRP and respiratory pathogen IgM in serum were detected.Results Among 65 specimens,30 were positive for IgM,accounting for 46.15%.Pathogen detection rates from high to low were 15 cases of influenza A virus,14 cases of mycoplasma pneumoniae,11 cases of influenza B virus,7 cases of legionella pneumophila,1 case of adenovirus,1 case of parainfluenza virus,and 0 cases of chlamydia pneumoniae and respiratory syncytial virus.Among the 65 specimens,10 were mixed infections,and the infections of the two pathogens were the most common,accounting for 60.00%(6/10),most of which were mycoplasma pneumoniae and influenza A virus infections,accounting for 30.00%.Three types of pathogen infections accounted for mixed infections,accounting for 40%(4/10),of which mycoplasma pneumoniae,influenza A virus and influenza B virus infections were the most common,accounting for 20%(2/10).10 cases of bacterial and viral infections in mixed infections were removed,and the remaining 55 cases were classified according to the bacterial group,viral group,and negative group,and the relationship between the types of respiratory infection pathogens and SAA,CRP were compared.The positive rate of CRP in the bacterial group was higher than that in the viral group,and the CRP in the viral group was higher than that in the negative group.The positive rate of SAA in the bacterial and viral groups was 100%,which was higher than that in the negative group.The difference was statistically significant(P<0.05).Conclusion IgM detection of respiratory pathogen spectrum provided a rapid and accurate diagnostic basis.CRP reflected early bacterial infection and has low sensitivity.SAA reflected early bacterial and viral inf

关 键 词：呼吸道感染性疾 淀粉样蛋白A C反应蛋白 呼吸道病原体谱IgM 诊断价值 

分 类 号：R56[医药卫生—呼吸系统] R446.6[医药卫生—内科学]