根除儿童口腔幽门螺杆菌预防胃内幽门螺杆菌感染的多中心研究  

A multicenter study on eradication of oral Helicobacter pylori in children to prevent gastric Helicobacter pylori infection

作　　者：黄超 彭伟强 吴海涛 程水颖 陈姣姣 赵庆波 钟海彬[6] 马健 赵莉 HUANG Chao;PENG Weiqiang;WU Haitao;CHENG Shuiying;CHEN Jiaojiao;ZHAO Qingbo;ZHONG Haibin;MA Jian;ZHAO Li(Department of Spleen and Stomach,Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University(Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine),Shenzhen 518104,China;General Department,Dongguan Dental Hospital,Dongguan 523000,China;Department of Dental Implantation,Dongguan Dental Hospital,Dongguan 523000,China;Department of Periodontology,Dongguan Dental Hospital,Dongguan 523000,China;Guangdong Etron Technology Development Co.,Ltd,Guangzhou 511442,China;Internal Medicine Area II,Wuhua Hospital of Traditional Chinese Medicine,Meizhou 514400,China;People's Hospital of Huangnan Tibetan Autonomous Prefecture of Qinghai Province,Huangnan 811300,China)

机构地区：[1]广州医科大学附属深圳沙井医院(深圳市中西医结合医院)脾胃病科,广东深圳518104 [2]东莞口腔医院综合科,广东东莞523000 [3]东莞口腔医院种植科,广东东莞523000 [4]东莞口腔医院牙周科,广东东莞523000 [5]广东医创时代科技发展有限公司,广东广州511442 [6]五华县中医医院内科Ⅱ区,广东梅州514400 [7]青海省黄南藏族自治州人民医院,青海黄南811300

出　　处：《中国医学物理学杂志》2021年第6期785-787,共3页Chinese Journal of Medical Physics

基　　金：广东省医学科研基金(B2019242)。

摘　　要：目的:探讨根除儿童口腔幽门螺杆菌(Hp)预防胃内Hp感染的可能性。方法:采用多中心前瞻随机研究,选取口腔Hp阳性但胃内Hp阴性的幼儿园儿童共计427例,随机分为使用“无幽梅”牙膏组与普通牙膏组,分别接受“无幽梅”牙膏和普通牙膏。疗程结束后,再次检测口腔Hp,将口腔Hp阳性及阴性患者各分为一组,1年后行C^(13)呼气试验检查,分析两组患者胃内Hp感染情况。口腔Hp检测方法采用特异度及敏感度双高的套式PCR方法。结果:随访1年,口腔Hp阴性组胃内Hp感染率为0.51%,口腔Hp阳性组胃内Hp感染率为6.51%,两组统计差异具有显著性(P<0.01)。结论:儿童根除口腔Hp可以降低胃内Hp感染的发生。Objective To investigate the possibility of preventing gastric Helicobacter pylori(Hp)infection by eradicating oral Hp in children.Methods A multicenter prospective randomized study was conducted on 427 kindergarten children who had Hp positive expression in oral cavity but Hp negative expression in stomach.According to the treatment,the children were randomly divided into two groups,namely wuyoumei toothpaste group and ordinary toothpaste group.After the completion of treatment course,oral Hp was detected again,and according to the detection results,the children were grouped into oral Hp positive expression group and negative expression group.One year later,C^(13) breath test was performed to analyze the gastric Hp infection in two groups.In the study,oral Hp was detected by nested PCR with high specificity and high sensitivity.Results One-year follow-up showed that the gastric Hp infection rate was 0.51%in oral Hp negative expression group and 6.51%in oral Hp positive expression group,with significant differences between two groups(P<0.01).Conclusion Eradication of oral Hp in children can reduce the incidence of gastric Hp infection.

关 键 词：口腔 胃 儿童 幽门螺杆菌感染 

分 类 号：R37[医药卫生—病原生物学] R573[医药卫生—基础医学]