补骨脂炮制方法优选的研究  

Research on Optimization of Processing Method of Psoraleae Fructus

作　　者：陈李东 朱日然[1] 张学顺[1] 刘晓倩 CHEN Li-dong;ZHU Ri-ran;ZHANG Xue-shun;LIU Xiao-qian(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Laohekou Center for Disease Control and Prevention,Xiangyang 441800,China)

机构地区：[1]山东中医药大学附属医院,山东济南250014 [2]老河口市疾病预防控制中心,湖北襄阳441800

出　　处：《食品与药品》2021年第3期197-202,共6页Food and Drug

基　　金：山东省中医药科技发展计划项目(编号:2019-0073补骨脂炮制工艺优选的研究)。

摘　　要：目的优选补骨脂的最佳炮制方法。方法以补骨脂素、异补骨脂素和补骨脂酚为测定指标,用高效液相色谱法(HPLC)测定比较补骨脂生品和各种炮制品色谱峰面积及含量变化,筛选最佳炮制方法。结果补骨脂通过炮制后其药用效果有效增强,毒性成分明显减弱,15种炮制方法中酒焙法最优。结论可选用酒制补骨脂作为其临床应用的炮制方法。Objective To optimize the processing method of Psoraleae fructus.Methods Psoralen,isopsoralen and bakuchiol from Psoraleae fructus were used as the indexes.An HPLC method was used to determine and compare the chromatographic peaks and contents of raw materials and processed products of Psoraleae fructus,to screen out the best processing method.Results The medicinal effect of Psoraleae fructus was effectively enhanced by processing,and the toxic components were markedly reduced.Wine-processed method was finally confirmed as the best method among the 15 processing methods.Conclusion Wine-processed method can be used as the processing method of Psoraleae fructus for the clinical application.

关 键 词：补骨脂 炮制方法 优选 

分 类 号：R283.3[医药卫生—中药学]