不同结构的左旋聚乳酸冠脉支架的力学行为研究  

Study on Mechanical Behavior of Different Structures of L-polylactic Acid Coronary Stent

作　　者：张园园 颜文涛 李建军 王盛章 ZHANG Yuanyuan;YAN Wentao;LI Jianjun;WANG Shengzhang(Institute of Biomedical Engineering and Technology,Academy for Engineering&Technology,Fudan University,Shanghai,200433;Institute of Biomechanics,Department of Aeronautics and Astronautics,Fudan University,Shanghai,200433)

机构地区：[1]复旦大学工程与应用技术研究院生物医学工程技术研究所,上海200433 [2]复旦大学航空航天系生物力学研究所,上海200433

出　　处：《生物医学工程学进展》2021年第2期63-67,共5页Progress in Biomedical Engineering

基　　金：国家自然科学基金(11872152)。

摘　　要：目的分析不同的结构尺寸对左旋聚乳酸支架的应变分布、回弹率、径向支撑力等性能的影响,为全降解支架的设计和优化提供参考依据。方法利用有限元数值模拟,对三种不同结构左旋聚乳酸冠脉支架的应变分布、压握及扩张回弹率和支撑力进行了分析,并辅以样品实验进行验证。结果数值模拟与实验结果基本一致,均表明:随着支架管材直径的增加,支架产生塑性变形的幅值和范围增大,与此同时,支架的回弹减小,径向支撑力增大。结论C结构左旋聚乳酸支架(3.3 mm外径管材)的应变分布,压握及扩张回弹率和径向支撑力等性能最好,可为全降解支架的的设计和优化提供参考。此外,有限元分析可以模拟支架的变形过程,用以评价支架的力学性能。Objective Analyzing the effect of different structures on the strain distribution,resilience rate,and radial support force of the L-polylactic acid stent is to provide a reference for the design and optimization of the fully degradable stent.Methods The strain distribution,crimping and expansion resilience rate and supporting force of three different structures of L-polylactic acid coronary stents were analyzed by finite element numerical simulation,and verified by experiments.Results The numerical simulation is basically consistent with the experimental results,and both show that as the diameter of the stent tube increases,the amplitude and range of the plastic deformation of the stent increase.At the same time,the stent's resilience decreases and the radial support force increases.Conclusion The C-structure L-polylactic acid stent(3.3 mm outer diameter tube)has the best strain distribution,resilience rate and radial support force,which can provide a reference for the design and optimization of the fully degradable stent.In addition,finite element analysis can simulate the deformation process of the stent to evaluate its mechanical properties.

关 键 词：左旋聚乳酸支架 有限元模拟 支架回弹 径向支撑力 

分 类 号：R318[医药卫生—生物医学工程]