IgE与sFcεRI在老年分泌性中耳炎患者外周血中的水平变化及其检测意义  

Changes and significance of IgE and sFcεRI in peripheral blood of elderly patients with secretory otitis media

作　　者：崔毅 周娟[1] 文浩杰[1] 沈丽敏[1] 唐金勇[1] 徐润 Cui Yi;Zhou Juan;Wen Haojie;Shen Limin;Tang Jinyong;Xu Run(Department of Otorhinolaryngology and Head and Neck Surgery,First People’s Hospital of Chenzhou City,Chenzhou,Hunan,423000,P.R.China;Otorhinolaryngology,Baoshan Branch of First People’s Hospital of Shanghai City,Shanghai,200940,P.R.China)

机构地区：[1]郴州市第一人民医院耳鼻咽喉头颈外科,湖南郴州423000 [2]上海市第一人民医院宝山分院耳鼻喉科,上海200940

出　　处：《老年医学与保健》2021年第3期648-651,共4页Geriatrics & Health Care

基　　金：郴州市第一人民医院院级科研项目(N2019-033);湖南省郴州市第一人民医院院内技术项目(XY201638)。

摘　　要：目的探究免疫球蛋白E(IgE)与免疫球蛋白E高亲和力抗体可溶同工型(sFcεRI)在老年分泌性中耳炎患者外周血中的变化及其检测意义。方法选择2018年1月-2021年1月郴州市第一人民医院收治的74例老年分泌性中耳炎患者纳入老年组,100例儿童分泌性中耳炎患者纳入儿童组,同期在我院体检健康者60例纳入对照组,比较3组血清IgE与sFcεRI水平,比较不同病情程度的老年患者血清IgE与sFcεRI水平,比较老年患者治疗前后的血清IgE与sFcεRI水平.采用spearman相关分析血清IgE、sFcεRI与老年分泌性中耳炎的发生及其病情程度的相关性,采用Logistic回归分析血清IgE、sFcεRI与老年分泌性中耳炎的关系。结果老年组和儿童组血清IgE水平显著高于对照组(P<0.05),血清sFcεRI水平显著低于对照组(P<0.05),而老年组与儿童组血清IgE和sFcεRI水平差异无统计学意义(P>0.05)。急性组、亚急性组与慢性组老年患者血清IgE水平依次显著上升(P<0.05),血清sFcεRI水平依次显著下降(P<0.05)。血清IgE水平与老年患者分泌性中耳炎的发生及其病情程度均呈正相关(P<0.05);血清sFcεRI与老年患者分泌性中耳炎的发生及其病情程度均呈负相关(P<0.05)。治疗后,老年患者血清IgE水平显著低于治疗前(P<0.05),血清sFcεRI水平显著高于治疗前(P<0.05)。Logistic回归分析显示,血清IgE水平升高及sFcεRI水平下降是老年分泌性中耳炎发生的危险因素(P<0.05)。结论老年分泌性中耳炎患者外周血中IgE呈高表达、sFcεRI呈低表达,其水平变化与老年分泌性中耳炎的发生、病情进展及转归情况关系密切。Objective To investigate the changes of immunoglobulin E(IgE)and sFcvarepsilon RI(sFcεRI)in peripheral blood of elderly patients with secretory otitis media(SOM)and their detection significance.Methods 74 elderly patients with SOM admitted to the First People’s Hospital of Chenzhou City from January 2018 to January 2021 were included in the elderly group,100 children with SOM were included in the child group,and 60 healthy people who received physical examination in the hospital during the same period were included in the control group.The levels of serum IgE and sFcεRI were compared among the three groups,the levels of serum IgE and sFcεRI among elderly patients with different degrees of disease were compared,and the levels of serum IgE and sFcεRI in elderly group were compared before and after treatment.Spearman correlation analysis was used to analyze the relationship between serum IgE and sFcεRI and the occurrence and severity of SOM in elderly patients.Logistic regression was used to analyze the relationship between serum IgE and sFcεRI and SOM in elderly patients.Results The serum IgE level of the elderly group and the child group was significantly higher than that of the control group(P<0.05),and the serum sFcεRI level was significantly lower than that of the control group(P<0.05).However,the difference in serum IgE and sFcεRI levels between the elderly group and the child group was not statistically significant(P>0.05).The serum IgE level of elderly patients in the acute group,subacute group and chronic group increased significantly in turn(P<0.05),and serum sFcεRI level decreased significantly in turn(P<0.05).The serum IgE level were positively correlated with the occurrence and severity of SOM in elderly patients(P<0.05)and the serum sFcεRI level was negatively correlated with the occurrence and severity of SOM in elderly patients(P<0.05).After treatment,the serum IgE level of elderly patients was significantly lower than that before treatment(P<0.05),and the serum sFcεRI level was signific

关 键 词：老年 分泌性中耳炎 免疫球蛋白E 免疫球蛋白E高亲和力抗体可溶同工型 病情程度 相关性 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]