妊娠期阴道炎患者病原菌分布及应用乳酸菌阴道胶囊联合维生素D的干预效果  

Distribution of pathogenic bacteria in vaginitis patients during pregnancy and intervention effect of lacidophilin vaginal capsule combined with vitamin D

作　　者：梅军华 刘菊梅 李甜 刘洁 MEI Jun-hua;LIU Ju-mei;LI Tian(Department of Obstetrics and Gynecology,,Huanggang Central Hospital,Huanggang Hubei 438000,China;Department of Obstetrics,Huanggang Central Hospital,Huanggang Hubei 438000,China)

机构地区：[1]黄冈市中心医院妇产科,湖北黄冈438000 [2]黄冈市中心医院产科,湖北黄冈438000

出　　处：《临床和实验医学杂志》2021年第12期1311-1314,共4页Journal of Clinical and Experimental Medicine

基　　金：中国管理科学研究院教育科学研究所科教创新研究重点课题(编号:KJCX5408)。

摘　　要：目的研究妊娠期细菌性阴道炎患者病原菌分布及应用乳酸菌阴道胶囊联合维生素D后临床疗效。方法回顾性选取2018年5月至2019年7月黄冈市中心医院收治的妊娠期细菌性阴道炎患者,按照入院后给予的治疗方法不同分为观察组(n=67)与对照组(n=79)。观察组给予外用乳酸菌阴道胶囊联合口服维生素D治疗,对照组给予外用乳酸菌阴道胶囊与甲硝唑胶囊治疗。采集2组阴道分泌物,通过细菌培养观察患者阴道微生态细菌分布情况。在治疗半个月后停药1周,观察2组治疗疗效、主要临床症状改善或消失时间及治疗不良反应。结果治疗前观察组共检出83株主要致病菌,其中革兰阴性菌31株(37.35%),革兰阳性菌52株(62.65%),以革兰阳性菌为主;治疗后革兰阳性菌减少至13株(46.43%),革兰阴性菌减少至15株(53.57%),差异有统计学意义(P<0.05)。对照组治疗前共检出101株细菌,其中革兰阴性菌36株(35.64%),革兰阳性菌65株(64.36%),也以革兰阳性菌为主;治疗后革兰阳性菌减少至31株(57.41%)、革兰阴性菌减少至23株(42.59%),差异有统计学意义(P<0.05)。治疗后观察组治疗有效率(86.57%)高于对照组(70.89%),阴道瘙痒症状改善/消失时间、阴道糜烂症状改善/消失时间为(5.31±0.72)、(9.53±0.48)d,短于对照组[(8.65±1.05)、(13.17±0.76)d],差异均有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论妊娠期细菌性阴道炎患者以革兰阳性菌分布为主,给予外用乳酸菌阴道胶囊联合口服维生素D治疗后,可有效抑制致病菌生长,临床疗效较高,且无明显不良反应。Objective To investigate the distribution of pathogenic bacteria in vaginitis patients during pregnancy and intervention effect of lacidophilin vaginal capsule combined with vitamin D.Methods Patients with bacterial vaginitis during pregnancy in Huanggang Central Hospital from May 2018 to July 2019 were selected retrospectively,and divided into the observation group(n=67)and the control group(n=79)according to different treatment methods.The observation group was treated with lacidophilin vaginal capsule combined with vitamin D,while the control group was treated with lacidophilin vaginal capsule and metronidazole capsule.The distribution of bacteria in vagina was observed by bacterial culture.The drug was discontinued for 1 week after half a month of treatment,and the therapeutic effects,time to improvement or disappearance of main clinical symptomsand,adverse reactions in the two groups were observed.Results A total of 83 main pathogenic bacteria were detected in the observation group before treatment,including 31 stains of Gram-negative bacteria(37.35%)and 52 stains of Gram-positive bacteria(62.65%).After treatment,the gram-positive bacteria decreased to 13(46.43%)and the gram-negative bacteria decreased to 15(53.57%),the difference was statistically significant(P<0.05).A total of 101 strains of bacteria were isolated in control group before treatment,including 36 Gram-negative bacteria(35.64%)and 65 Gram-positive bacteria(64.36%).After treatment,gram-positive bacteria decreased to 31(57.41%)and gram-negative bacteria decreased to 23(42.59%),the difference was statistically significant(P<0.05).Gram positive bacteria were the main bacteria in both groups.After treatment,the effective rate of the observation group(86.57%)was higher than that of the control group(70.89%),and the time for improvement/disappearance of vaginal itching symptoms and vaginal erosion symptoms in the observation group were(5.31±0.72)and(9.53±0.48)days,which were shorter than thoe in the control group[(8.65±1.05),(13.17±0.76)d],the di

关 键 词：妊娠期阴道炎 病原菌 乳酸菌阴道胶囊 维生素D 疗效 

分 类 号：R711.31[医药卫生—妇产科学]