三氟甲基酰腙N-烃基化反应研究  

Study on N-Alkylation Reactions of Trifluoromethylated Acylhydrazones

作　　者：杨金宇 黄丹凤[1] 王克虎[1] 王君姣 苏瀛鹏[1] 邓周斌 杨天宇[1] 胡雨来[1] Yang Jinyu;Huang Danfeng;Wang Kehu;Wang Junjiao;Su Yingpeng;Deng Zhoubin;Yang Tianyu;Hu Yulai(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070)

机构地区：[1]西北师范大学化学化工学院,兰州730070

出　　处：《有机化学》2021年第5期2029-2037,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21662030,22061037)资助项目.

摘　　要：探索了三氟甲基酰腙的N-烃基化反应,得到了一系列N-烃基取代的三氟甲基酰腙衍生物.其结构经1H NMR和13C NMR、HRMS等确证.该方法具有反应条件温和、产率高及操作简单等优点,为合成N-烃基取代的三氟甲基酰腙类化合物提供了一种简单高效的方法.The N-alkylation reaction of trifluoromethylated acylhydrazones was investigated,and a series of N-alkyl trifluoromethyl acylhydrazones were afforded in good yield.Their structures were confirmed by 1H NMR,13C NMR and HRMS analysis.The strategy has advantages of simple and mild reaction conditions,wide scope of substrates and good yields.This protocol provides an efficient and new method for the synthesis of N-alkyl substituted trifluoromethyl acylhydrazones.

关 键 词：三氟甲基酰腙 卤代烃 Α Β-不饱和酯 N-烃基化 

分 类 号：O621.25[理学—有机化学]