乙酸铵催化的酚与多聚甲醛的甲酰化反应研究  

Formylation of Phenols and Paraformaldehyde Catalyzed by Ammonium Acetate

作　　者：李倩 杨丽[1] 刘伟[1] 王天昀 朱月杰 杜正银[1] Li Qian;Yang Li;Liu Wei;Wang Tianyun;Zhu Yuejie;Du Zhengyin(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070)

机构地区：[1]西北师范大学化学化工学院,兰州730070

出　　处：《有机化学》2021年第5期2038-2044,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21262028,21762039);甘肃省自然科学基金(No.20JR5RA521)资助项目.

摘　　要：在乙酸铵作为催化剂的条件下,萘酚和多聚甲醛在醋酸溶液中反应,成功合成了一系列羟基萘甲醛,收率最高达86%.将该方法应用于苯酚及取代苯酚的甲酰化反应,以42%~58%的中等收率得到水杨醛类化合物.根据反应结果提出了可能的作用机理.该方法不使用任何金属试剂,具有反应条件温和、操作简单及成本低廉的特点.The reaction of naphthol and paraformaldehyde in acetic acid solution with ammonium acetate as a catalyst resulted in the synthesis of a series of hydroxynaphthalenes in yields of up to 86%.Several phenols were also transformed into the corresponding salicylaldehydes under the same reaction conditions in moderate yields of 42%~58%.A rational mechanism was also proposed based on the facts of experimental observations.This metal-free process has the advantages of mild reaction conditions,simple operation and low cost.

关 键 词：萘酚 苯酚 多聚甲醛 甲酰化反应 绿色合成 

分 类 号：O621.251[理学—有机化学]