石斛根中三个新的菲醌类化合物  

Three New Phenanthraquinones from the Root of Dendrobium nobile

作　　者：刘英豪 林芳霞 谭银丰[2] 杨静雨 张斌 周学明[1,3] 宋鑫明[1,3] Liu Yinghao;Lin Fangxia;Tan Yinfeng;Yang Jingyu;Zhang Bin;Zhou Xueming;Song Xinming(Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158;Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs,Hainan Medical College,Haikou 570216;Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158)

机构地区：[1]海南师范大学化学与化工学院热带药用资源化学教育部重点实验室,海口571158 [2]海南医学院海南省热带药用植物研究开发重点实验室,海口570216 [3]海南师范大学化学与化工学院热带药用植物化学海南省重点实验室,海口571158

出　　处：《有机化学》2021年第5期2112-2115,共4页Chinese Journal of Organic Chemistry

基　　金：海南省自然科学基金(No.218QN234);海南省热带药用植物研究开发重点实验室开放研究(No.KF202002);国家自然科学基金(Nos.21662012,41866005);教育部创新研究团队(No.IRT-16R19)资助项目.

摘　　要：综合运用多种现代色谱技术对兰科石斛属植物石斛Dendrobium nobile Lindl.根中的化学成分进行了系统的分离纯化,从其根的乙醇提取物中分离得到了phenanobiles A~C(1~3),6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione(4)和ephemeranthoquinone(5)5个菲醌类化合物.采用多种波谱技术确定了这些化合物的结构,其中化合物1~3为新的菲醌类化合物.化合物1~5的体外抗肿瘤活性评价结果表明它们对3种肿瘤细胞株(HL-60,A549以及MCF-7)显示出体外生长抑制活性.Three new phenanthraquinones,phenanobiles A~C(1~3),together with two known phenanthraquinones 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione(4)and ephemeranthoquinone(5),were isolated from the root of Dendrobium nobile.Their structures were elucidated using comprehensive spectroscopic methods.The antitumor activities of compounds 1~5 were evaluated against three cancer cell lines(HL-60,A549 and MCF-7).Compounds 1~5 exhibited inhibitory effects against three cancer cell lines HeLa,MCF-7 and A549 in vitro.

关 键 词：石斛属 石斛 菲醌 抗肿瘤活性 

分 类 号：R284[医药卫生—中药学]