HBr催化α-溴代甲基酮类化合物的全脱溴反应研究  

Study on the Debromination ofα-Bromomethyl Ketones Catalyzed by HBr

作　　者：郑梦霞 曾竟 买里克扎提•买合木提 阿布都热西提•阿布力克木 Zheng Mengxia;Zeng Jing;Meihemuti Mailikezhati;Abulikemu Abudu Rexit(Department of Chemistry,Xinjiang Normal University,Urumqi 830054;School of Chemical Engineering,Xinjiang University,Urumqi 830046)

机构地区：[1]新疆师范大学化学系,乌鲁木齐830054 [2]新疆大学化工学院,乌鲁木齐830046

出　　处：《有机化学》2021年第5期2121-2126,共6页Chinese Journal of Organic Chemistry

基　　金：新疆维吾尔自治区2017年自治区“天山青年计划”(No.2017Q026)资助项目。

摘　　要：报道了HBr催化下以水为氢源的α-溴代甲基酮类化合物的脱溴化反应.以α-溴代甲基酮类化合物为原料,四氢呋喃为溶剂,α-溴代甲基酮与质量分数5%的氢溴酸的物质的量比为1.0∶0.2时,在180℃下反应5~14 h,分离产率高达94%[高效液相(HPLC)产率96%]的脱溴产物.该方法无金属催化剂参与,催化剂价格低廉,所有产物均经1H NMR和13C NMR结构确证.The debromination reaction ofα-bromomethylketone compounds was achieved by using water as the hydrogen source under the catalysis of HBr.Usingα-bromomethylketones as raw materials,tetrahydrofuran as solvent,when the molar ratio ofα-bromomethylketone to 5%mass fraction hydrobromic acid was 1.0∶0.2,the debrominated product could be obtained with a isolated yield of 94%[high performance liquid chromatography(HPLC)yield 96%]by reacting at 180℃for 5~14 h.All products were confirmed by 1H NMR and 13C NMR spectra.

关 键 词：α-溴代甲基酮类化合物 HBR 脱溴 

分 类 号：O621.251[理学—有机化学]