苯磺酸左旋氨氯地平对轻中度高血压的疗效及动态血压变化  

Effect of levamlodipine besylate on mild to moderate hypertension and the changes of ambulatory blood pressure

作　　者：郑林筠 许洁伟 ZHENG Lin-yun;XU Jie-wei(Department of Electrical Engineering,Affiliated Jinhua Hospital,Affiliated Jinhua Hospital,Zhejiang Universtiy,School of Medicine,Jinhua 321000,Zhejiang Province,China;Department of Cardiology,Affiliated Jinhua Hospital,Affiliated Jinhua Hospital,Zhejiang Universtiy,School of Medicine,Jinhua 321000,Zhejiang Province,China)

机构地区：[1]浙江大学医学院附属金华医院电生理科,浙江金华321000 [2]浙江大学医学院附属金华医院心内1科,浙江金华321000

出　　处：《中国临床药理学杂志》2021年第12期1491-1493,1497,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察苯磺酸左旋氨氯地平对轻中度高血压的治疗效果及动态血压变化情况。方法将82例患者分为对照组41例与试验组41例。对照组给予苯磺酸氨氯地平,起始剂量每次5 mg,每天1次,口服;连续给药7 d后若血压未出现明显改善,则继续提升药物剂量,但总剂量需低于15 mg·d^(-1)。试验组给予苯磺酸左旋氨氯地平片,起始剂量每次2.5 mg,每天1次,口服,连续给药7d后若血压未出现明显改善,则继续提升药物剂量,但总剂量需低于5 mg·d^(-1)。2组治疗时间均为14 d。比较2组的动态血压指标[24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、24 h收缩压平滑指数(24 h SIS)、24 h舒张压平滑指数(24 h SID)]、血清学指标[同型半胱氨酸(Hcy)、脑钠肽(BNP)]、临床疗效以及治疗过程中的药物不良反应发生情况。结果治疗后,试验组和对照组的24 h SBP分别为(135.69±10.07)和(137.35±9.69)mm Hg,24 h DBP分别为(84.15±5.93)和(85.36±7.76)mm Hg,24 h SIS分别为1.52±0.27和1.49±0.25,24 h SID分别为1.55±0.28和1.53±0.27,Hcy分别为(15.93±1.99)和(16.15±2.72)μmol·L^(-1),BNP分别为(63.38±11.96)和(67.28±13.28)pg·m L^(-1),差异均无统计学意义(均P>0.05)。试验组和对照组的总有效率分别为97.56%(40例/41例)和92.68%(38例/41例),差异无统计学意义(P>0.05)。试验组和对照组在治疗过程中的药物不良反应发生率分别为2.44%(1例/41例)和14.63%(6例/41例),差异有统计学意义(P<0.05)。结论轻中度高血压患者采用苯磺酸氨氯地平或苯磺酸左旋氨氯地平片单独口服治疗的情况下,短期内控制血压的效果较为接近,对血清学因子的影响程度也类似,但苯磺酸左旋氨氯地平的用药剂量较小、药物不良反应发生率低。ObjectiveTo observe the therapeutic effect of levamlodipine besylate on mild to moderate hypertension and changes in ambulatory blood pressure.Methods The 82 patients were divided into41 cases in control group and 41 cases in treatment group.Control group was given amlodipine besylate tablets,the initial dose was 5 mg each time,qd,orally.If the blood pressure does not improve significantly after continuous administration for 7 d,continue to increase the drug dose,but the total dose must be less than 15 mg·d^(-1).Treatment group was given levamlodipine besylate tablets,the initial dose was 2.5 mg each time,qd,orally.If the blood pressure does not improve significantly after continuous administration for 7 d,continue to increase the drug dose,but the total dose must be less than 5 mg·d^(-1).The treatment time for both groups was 14 d.The dynamic blood pressure indicators of the two groups[24 h average systolic blood pressure(24 h SBP),24 h average diastolic blood pressure(24 h DBP),24 h systolic blood pressure smoothing index(24 h SIS),24 h diastolic blood pressure smoothing index(24 h SID)],serological indicators[homocysteine(Hcy),brain natriuretic peptide(BNP)],clinical effect and adverse drug reactions during treatment in two groups were compared.Results After treatment,the 24 h SBP of treatment group and control group were(135.69±10.07)and(137.35±9.69)mm Hg,24 h DBP were(84.15±5.93)and(85.36±7.76)mm Hg,24 h SIS were 1.52±0.27 and 1.49±0.25,24 h SID were 1.55±0.28 and 1.53±0.27,Hcy were(15.93±1.99)and(16.15±2.72)μmol·L^(-1),BNP were(63.38±11.96)and(67.28±13.28)pg·m L^(-1),all without significant difference(all P>0.05).The total effective rates of treatment group and control group were 97.56%(40 cases/41cases)and 92.68%(38 cases/41 cases),without significant difference(P>0.05).The incidence of adverse drug reactions in treatment group and control group during treatment were 2.44%(1 case/41 cases)and 14.63%(6cases/41 cases),with significant difference(P<0.05).Conclusion When patients with mild to

关 键 词：苯磺酸左旋氨氯地平 高血压 动态血压变化 血管功能 

分 类 号：R972.4[医药卫生—药品]