中药熏蒸辅助艾拉莫德治疗活动期类风湿关节炎临床研究  

Clinical Study of Chinese Medicine Fumigation Combined with Iguratimod for Rheumatoid Arthritis at Active Stage

作　　者：秦理[1] 杨孝兵[1] 刘丽敏[1] 龙小琴[1] 邵丰[1] QIN Li;YANG Xiaobing;LIU Limin;LONG Xiaoqin;SHAO Feng

机构地区：[1]湖州市第三人民医院,浙江湖州313000

出　　处：《新中医》2021年第11期88-92,共5页New Chinese Medicine

基　　金：湖州市科技局课题(2013GYB09)。

摘　　要：目的:观察中药熏蒸辅助艾拉莫德治疗活动期类风湿关节炎的临床疗效。方法:将96例活动期类风湿关节炎患者,按数字奇偶法分为熏蒸组与常规组各48例,常规组给予西药艾拉莫德治疗,熏蒸组在常规组治疗的基础上采用中药熏蒸辅助治疗,疗程结束后观察2组临床疗效。结果:治疗后,熏蒸组临床总有效率为95.83%,常规组临床总有效率为81.25%,组间比较,差异有统计学意义(P<0.05)。2组治疗后关节压痛数、关节肿胀数、晨僵时间及视觉模拟评分法(VAS)评分较治疗前均降低,熏蒸组关节压痛数、关节肿胀数、晨僵时间及VAS评分均低于常规组(P<0.05)。2组治疗后风湿实验室指标血清类风湿因子(RF)、C-反应蛋白(CRP)、红细胞沉降率(ESR)水平较治疗前均降低,熏蒸组血清RF、CRP、ESR水平均低于常规组(P<0.05)。2组治疗后血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平较治疗前降低,熏蒸组血清TNF-α、IL-1β水平低于常规组(P<0.05)。结论:针对活动期类风湿关节炎采用中药熏蒸辅助艾拉莫德治疗,与单用艾拉莫德比较,有利于提升临床疗效,减轻临床症状,缓解疼痛,改善实验室指标,减轻炎症反应,可作为临床治疗类风湿关节炎的一种有效辅助方法。Objective: To observe the clinical effect of Chinese medicine fumigation combined with iguratimod for rheumatoid arthritis at active stage. Methods:A total of 96 cases of patients with rheumatoid arthritis at active stage were divided into the fumigation group and the routine group according to odd-even number grouping method,48 cases in each group. The routine group was treated with iguratimod, and the fumigation group was additionally treated with fumigation with Chinese medicine as an adjuvant therapy based on the treatment of the routine group. After treatment, the clinical effect was observed in the two groups. Results: After treatment, the total clinical effective rate was 95.83% in the fumigation group and 81.25% in the routine group,the difference being significant between the two groups(P<0.05).The tender joint count,swollen joint count,the time of morning stiffness and scores of Visual Analogue Scale(VAS) in the two groups were decreased when compared with those before treatment,and the four indexes in the fumigation group were all lower than those in the routine group(P<0.05). After treatment, levels of laboratory indicators of rheumatism, namely rheumatoid factor(RF),C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR) in serum in the two groups were decreased when compared with those before treatment,and the three indicators in the fumigation group were lower than those in the routine group(P<0.05).After treatment,levels of interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) in serum in the two groups were decreased when compared with those before treatment,and the two levels in the fumigation group were lower than those in the routine group(P<0.05). Conclusion: In the treatment of rheumatoid arthritis at active stage,compared with the simple use of iguratimod,the therapy of Chinese medicine fumigation combined with iguratimod can better improve the clinical effect, relieve clinical symptoms and pain, improve laboratory indicators, and alleviate inflammatory factor responses in se

关 键 词：类风湿关节炎 活动期 中药熏蒸 艾拉莫德 风湿指标 

分 类 号：R593.22[医药卫生—内科学]