脂类代谢异常与围术期神经认知障碍关系研究进展  

Relationship between abnormal lipid metabolism and perioperative neurocognitive disorders

作　　者：康霞 李普乐 张加强 KANG Xia;LI Pu-le;ZHANG Jia-qiang(Department of Anesthesiology and Perioperative Medicine,Zhengzhou University People's Hospital,Henan Provincial People's Hospital,Zhengzhou,Henan 450003,China)

机构地区：[1]郑州大学人民医院河南省人民医院麻醉与围术期医学科,河南郑州450003

出　　处：《中华实用诊断与治疗杂志》2021年第6期636-638,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(81771149)。

摘　　要：围术期神经认知障碍是手术和麻醉后老年患者的常见并发症。围术期神经认知障碍与术后致残率和病死率增加具有相关性。围术期神经认知障碍的发病机制尚不明确。脂类是人体三大代谢物质之一,脂类代谢异常与神经退行性疾病的发生具有相关性。与脂类代谢相关的生物学因子可能是围术期神经认知障碍的危险因子。本文就脂类代谢异常与围术期神经认知障碍关系的研究进展作一综述。Perioperative neurocognitive disorders(PND)are a common postoperative complication in elder patients after surgery and anesthesia.PND are associated with the increased morbidity and mortality after surgery.The pathogenesis of PND has not yet been fully elucidated.As one of three major metabolites in human body,abnormal lipid metabolism is associated with the development of neurodegenerative diseases.The biological factors related to abnormal lipid metabolism may be the risk factors of PND.This paper reviews the research progress of the relationship between abnormal lipid metabolism and PND.

关 键 词：围术期神经认知障碍 血脂异常 代谢组学 

分 类 号：R589.2[医药卫生—内分泌] R749.1[医药卫生—内科学]