血清IgE水平与冠心病患者冠脉病变严重程度的相关性研究  

Correlation between serum IgE level and severity of coronary artery disease in patients with coronary heart disease

作　　者：陈小林[1] 李先凡 罗勤[2] CHEN Xiaolin;LI Xianfan;LUO Qin(Laboratory Department of Pingxiang People's Hospital,Pingxiang People's Hospital,Pingxiang 337000;Department of Cardiovascular Medicine,Pingxiang People's Hospital,Pingxiang 337000)

机构地区：[1]江西省萍乡市人民医院检验科,萍乡337000 [2]江西省萍乡市人民医院血管内科,萍乡337000

出　　处：《江西医药》2021年第5期577-580,592,共5页Jiangxi Medical Journal

基　　金：江西省卫健委科技计划项目,编号202140599。

摘　　要：目的探讨血清IgE水平与冠心病患者冠脉病变程度的相关性。方法将我院心内科收治的164例患者作为研究对象,根据冠脉造影结果分为冠心病组104例和非冠心病组60例,冠心病组根据临床症状分为稳定型心绞痛组(SAP)、不稳定型心绞痛组(UAP)和急性心肌梗死组(AMI),动脉病变程度通过检测狭窄病变血管的数量进行评估,并应用Gensini评分进行量化,采用免疫化学发光法测定患者血清IgE水平。比较冠心病组和非冠心病组患者血清IgE水平的差异,并分析血清IgE等级与患者冠脉病变支数及Gensini积分的相关性。结果冠心病患者(n=104)组血清IgE水平高于非冠心病(n=60)组[66.72±9.76 vs.26.43±8.81)KU/L,P<0.001]。AMI、UAP组的血清IgE水平(92.43±10.85 KU/L、56.43±9.76 KU/L)均高于SAP组(40.72±6.29 KU/L),差异有统计学意义(P<0.05),且多支血病变组患者血清IgE水平显著高于单支血管病变患者(P<0.05)。IgE水平和患者Gensini积分呈正相关,并随着IgE分级水平增加冠心病Gensini积分增加。结论冠心病患者的血清IgE水平升高,且与血管病变严重程度存在相关性,可用于辅助冠心病的诊断及病情监测。Objective To explore the correlation between serum IgE level and artery lesions in patients with coronary heart disease.Methods 164 patients in our hospitalt were divided into coronary heart disease group(104 cases)and non-coronary heart disease group(60 cases).The coronary heart disease group was classified three goup:stable angina pectoris(SAP),unstable angina pectoris(UAP)and acute myocardial infarction(AMI),the degree of arterial lesions is assessed by detecting the number of stenotic lesions and the Gensini score is used for quantification.And then the serum IgE level of patients are measured by chemiluminescence.The difference in serum IgE levels between the coronary heart disease group and the non-coronary heart disease group was compared,and the correlation between the serum IgE level and the number of coronary artery disease and Gensini score was analyzed.Results The serum IgE level[66.72±9.76,KU/L]of patients with coronary heart disease(N=104)was higher than that of patients[26.43±8.81 KU/L]without coronary heart disease(n=60)(P<0.001).The serum IgE level in AMI(92.43±10.85 KU/L)and UAP(56.43±9.76 KU/L)groups were higher than that in SAP group(40.72±6.29 KU/L),and the serum IgE level of patients with multi-vessel disease group was significantly higher than the patients with single-vessel disease group(P<0.05).There was a positive correlation between the IgE level and the Gensini score in patients,and the Gensini score in CHD increased with the increase of IgE grading level.Conclusion The elevated serum IgE level in patients with coronary heart disease is correlated with the severity of vascular lesions,which can be used to assist the diagnosis and monitoring of coronary heart disease.

关 键 词：IGE 冠心病 病变程度 肥大细胞 

分 类 号：R541.4[医药卫生—心血管疾病]