甲状腺癌患者Cyclin D1及Ki-67的临床意义研究  被引量:2

Clinical significance of Cyclin D1 and Ki-67 in patients with thyroid carcinoma

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作  者:王莹 韩恩善[2] 夏潇 WANG Ying;HAN Enshan;XIA Xiao(Wuzhong People's Hospital,Wuzhong 751100,China;Department of Pathology,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区:[1]宁夏吴忠市人民医院,宁夏吴忠751100 [2]宁夏医科大学总医院病理科,宁夏银川750004

出  处:《宁夏医学杂志》2021年第6期519-521,共3页Ningxia Medical Journal

摘  要:目的探讨细胞周期蛋白(Cylin D1)及增殖细胞核抗原(Ki-67)在甲状腺癌(TC)患者中的表达及其与病理特征和预后的相关性。方法收集131例TC组织及癌旁正常组织的石蜡标本,收集患者的临床病理资料,并通过免疫组化法检测Cylin D1及Ki-67的阳性表达情况,分析其与患者临床病理特征及预后的相关性。结果在TC患者中,Cyclin D1及Ki-67表达在性别、年龄、组织病理学类型和荚膜浸润方面差异无统计学意义(P>0.05)。Cyclin D1及Ki-67表达阳性率与肿瘤直径、病理分期及淋巴结转移比较差异有统计学意义(P<0.05),同时其表达与患者5年生存率比较差异有统计学意义(P<0.05)。结论Cyclin D1及Ki-67与TC癌患者病理特征及不良预后相关,可能成为TC临床诊断及预后评估生物标志物的指标。Objective To investigate the expression of cylin D1 and Ki-67 in patients with thyroid cancer and their correlation with the pathological characteristics and prognosis.Methods 131 paraffin specimens of TC tissues and adjacent normal tissues were collected,and the clinical pathological data of the patients were collected.The positive expression of cylin D1 and Ki-67 were detected by immunohistochemistry and the correlation with clinicopathological features and prognosis of the patients was analyzed.Results In thyroid carcinoma,the expressions of Cyclin D1 and Ki-67 were not statistically different in gender,age,histopathological type,and capsular invasion(P>0.05).However,the positive rates of Cyclin D1 and Ki-67 were significantly correlated with tumor diameter,pathological stage and lymph node metastasis(P<0.05),and their expression was significantly correlated with five-year survival rate of patients.Conclusion Cyclin D1 and Ki-67 are related to the pathological characteristics and poor prognosis of patients with thyroid carcinoma,and have the potential to become biomarkers for clinical diagnosis and prognosis evaluation of thyroid carcinoma.

关 键 词:细胞周期蛋白 增殖细胞核抗原 甲状腺癌 病理特征 预后 

分 类 号:R581[医药卫生—内分泌]

 

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