玫瑰红景天活性成分络塞维的合成研究  

Synthesis Research of Active Constituent Rosavin from Rhodiola Rosea

作　　者：钟婷 胡亚丹 苏进[1] 杨淑珍[1] 何贝桥 张园园[1] ZHONG Ting;HU Ya-dan;SU Jin;YANG Shu-zhen;HE Bei-qiao;ZHANG Yuan-yuan(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中药学院,北京102488

出　　处：《中国现代中药》2021年第5期781-785,806,共6页Modern Chinese Medicine

摘　　要：目的:建立一种玫瑰红景天活性成分络塞维的合成方法,并进行工艺优化。方法:以肉桂醇为原料,与2,3,4,6-四-O-乙酰基-α-D-吡喃溴代葡萄糖进行糖苷化反应,脱保护得肉桂醇基-β-D-吡喃葡萄糖苷,并通过保护与脱保护策略将其改造成糖受体,与2,3,4-三-O-乙酰基-β-L-溴代阿拉伯糖进行合成,最后脱保护得络塞维。结果:通过该方法合成了二糖苷类化合物络塞维,其结构经核磁共振氢谱(1H-NMR)和核磁共振碳谱(13C-NMR)表征。结论:合成方法反应条件温和、操作简单、成本低,获得的产物和关键中间体可用于相关化合物的深入研究。Objective:To establish and optimize the synthetic method of an active ingredient named rosavin from Rhodiola rosea L.Methods:Using cinnamyl alcohol as raw material,glucosylation with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide,and then cinnamyl-β-D-glucopyranoside was obtained by deprotection.What′s more,it was transformed into a sugar receptor by protection and deprotection strategy and reacted with 2,3,4-tri-O-acetyl-β-L-arabinopryanosyl bromide.Finally,it was deprotected to obtain rosavin.Results:The diglycoside compound rosavin was synthesized by this method,and its structure was characterized by 1H-NMR and 13C-NMR.Conclusion:This synthetic method has the advantages on mild reaction conditions,simple operation and low cost.The compounds and key intermediates can be used for as a basis for further study.

关 键 词：玫瑰红景天 络塞维 三苯基氯甲烷 合成 

分 类 号：R284[医药卫生—中药学]