基于信息熵理论的黄芪三七复方提取工艺优选  

Optimization of Extraction Technology for Huangqi Sanqi Decoction Based on Information Entropy Theory

作　　者：张仕瑾 兰杨 王娅俐 郭廷东[1,2] 张燕 唐志立[1,2] 谢席胜 ZHANG Shi-jin;LAN Yang;WANG Ya-li;GUO Ting-dong;ZHANG Yan;TANG Zhi-li;XIE Xi-sheng(Department of Pharmacy,The Second Clinical Medical College of North Sichuan Medical College,Nanchong Central Hospital,Nanchong 637000,China;Nanchong Key Laboratory of Individualized Drug Therapy,Nanchong 637000,China;Department of Nephrology,The Second Clinical Medical College of North Sichuan Medical College,Nanchong Central Hospital,Nanchong 637000,China)

机构地区：[1]川北医学院第二临床医学院/南充市中心医院药学部,四川南充637000 [2]个体化药物治疗南充市重点实验室,四川南充637000 [3]川北医学院第二临床医学院/南充市中心医院肾内科,四川南充637000

出　　处：《中国现代中药》2021年第5期854-860,共7页Modern Chinese Medicine

基　　金：四川省科技厅重点研发项目(21ZDYF2053);四川省中医管理局项目(2018JC037,2018YY007);南充市首批重点实验室建设项目(NCKL201711);南充市市校合作科研专项(NSMC20170109,18SXHZ0453);川北医学院科研发展计划项目(CBY18-A-YB32);南充市哲学社会科学重点研究基地项目(YAZX19-Z-04,YAZX19-Y-02)。

摘　　要：目的:应用信息熵理论优选黄芪三七复方的提取工艺。方法:以毛蕊异黄酮葡萄糖苷、阿魏酸、三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的提取量及浸膏得率为评价指标,应用信息熵赋权法确定各指标的权重系数,实现对正交试验提取工艺参数的优选。结果:最佳提取工艺为加10倍量水,提取4次,每次30 min。结论:优化后的提取工艺稳定可行,可为该处方的进一步开发提供参考。Objective:To optimize the extraction technology of Huangqi Sanqi decoction by information entropy theory.Methods:With the contents of calycosin-7-O-β-D-glucoside,ferulic acid,notoginsenoside R1,ginsenoside Rg1,ginsenoside Rb1 and the yield of extract as comprehensive evaluation indexes in order to optimize the extraction process parameters of orthogonal test,the weight coefficient of each index was determined by the information entropy weight method.Results:The optimized extraction technology was as follows:reflux extraction for 4 times with 10 folds water,for 30 min each time.Conclusion:The optimized method is stable and reliable,and can provide the reference for further development and utilization of the formula.

关 键 词：信息熵理论 黄芪三七复方 正交试验 提取工艺 

分 类 号：R284.2[医药卫生—中药学]