氯吲哚的合成工艺研究  

Study on Synthesis Technology of Chlorindole

作　　者：梅宇 廖前进 胡筱茜 郭瑞佳 何晓强[1] Mei Yu;Liao Qianjin;Hu Xiaoxi;Guo Luijia;He Xiaoqiang(School of Chemical and Pharmacy,Jingchu University of Technology,Hubei Jingmen 448000)

机构地区：[1]荆楚理工学院化工与药学院,湖北荆门448000

出　　处：《江西化工》2021年第3期100-101,共2页Jiangxi Chemical Industry

基　　金：荆楚理工学院校级科研项目ZR201408。

摘　　要：以2-氯苯胺、水合三氯乙醛、硫酸羟胺为原料,通过Sandmeyer反应合成7-氯靛红,再由氢化铝锂乙醚还原体系制备得7-氯吲哚;考察了酰胺化反应温度和反应时间、成环反应温度对反应收率的影响;通过对实验结果进行分析,发现在酰胺化反应温度为85℃、反应时间1.5h,关环反应温度为80℃时,产率最高,可达到54.3%。Using 2-chloroaniline,trichloroacetaldehyde hydrate and hydroxylamine sulfate as raw materials,7-chloroindole was synthesized by sandmeyer reaction,and then 7-chloroindole was prepared by reduction system of aluminum hydride lithium ether.The effects of amide reaction temperature,reaction time and cyclization reaction temperature on the reaction yield were investigated.The results showed that the yield was the highest when the amide reaction temperature was 85℃and the reaction time was 1.5h,and the reaction temperature was 80℃.The yield is the highest,which can reach 54.3%.

关 键 词：2-氯苯胺 Sandmeyer反应 还原体系 吲哚 

分 类 号：TQ251.3[化学工程—有机化工]