妊娠合并干燥综合征患者母儿结局及相关因素分析  

Analysis of maternal and fetal outcomes and related factors in pregnancy with sicca syndrome

作　　者：杨京晶[1] 梁梅英[1] YANG Jingjing;LIANG Meiying(Department of Obstetrics and Gynecology,Peking University People's Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院妇产科,100044

出　　处：《中国妇产科临床杂志》2021年第3期228-230,共3页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的探讨妊娠合并原发性干燥综合征患者母儿结局及相关因素。方法选取2008年1月至2020年5月间就诊于北京大学人民医院产科的原发性干燥综合征患者52例为研究组;随机选取同期在本院建档的单胎妊娠260例作为正常对照组。研究组按照诊断时间分为孕前诊断组和孕期诊断组。结果 52例患者共56次妊娠,无孕产妇死亡,共获得活产新生儿55例(98.2%),胎死宫内1例次(1.8%)。分娩孕周(38.15±1.90),阴道分娩例27例(48.2%),剖宫产29例(51.8%)。研究组与对照组平均年龄[(31.89±3.55)vs(30.81±3.73)]岁,P=0.035;平均分娩孕周[(38.15±1.90) vs (39.36±1.23)]周,P <0.001;新生儿平均体重[(2 985.27±515.90)vs(3 372.54±431.87)]g,P <0.001;早产(16.1%vs 3.8%,P=0.002);子痫前期(5.4%vs 0.8%,P=0.041)、剖宫产率(51.8%vs 22.7%,P <0.001)均低于对照组,差异有统计学意义(P <0.05)。孕期诊断组较孕前诊断组分娩孕周低[(36.26±2.76)vs (38.34±1.73)]周,(P=0.018),子痫前期的发生率高(33.3%vs 2%,P=0.028),差异有统计学意义(P <0.05)。结论妊娠合并原发性干燥综合征患者妊娠并发症高,早产、子痫前期发生率增加。Objective To investigate obstetrical outcomes and associated factors of pregnancy with primary sicca syndrome(Sjogren’s syndrome).Methods 52 cases with primary sicca syndrome treated in the Department of Obstetrics, Peking University People’s Hospital from January 2008 to May 2020 were selected retrospectively as the study group, and 260 cases of singleton pregnancy during the same period were randomly selected as the normal control group.The study group was divided into two subgroups according to the diagnosed time,diagnosed during pregnancy or before.Results There were 56 pregnancies in 52 patients, with no maternal death.55 cases(98.2%) were born alive and 1 case(1.8%) of intrauterine death.The gestational age of delivery was(38.15±1.90) weeks.There were 27 cases of vaginal delivery(48.2%) and 29 cases of cesarean section(51.8%).The incidence of two groups were different statistically, in maternal age[(31.89±3.55)% vs(30.81±3.73), P =0.035], gestational age at delivery[(38.15±1.90) vs(39.36±1.23), P < 0.001], neonatal weight [(2 985.27±515.90) vs(3 372.54±431.87), P < 0.001], premature delivery(16.1%vs 3.8%, P =0.002), preeclampsia(5.4%vs 0.8%, P =0.041), cesarean section rate(51.8%vs 22.7%, P < 0.001).Pregnant women with sicca syndrome who first presented during pregnancy differed from those diagnosed before pregnancy in terms of gestational age at delivery [(36.26±2.76) vs(38.34±1.73), P =0.018] and incidence of preeclampsia(33.3% vs 2%, P =0.028).Conclusion Pregnancy with sicca syndrome is high risk pregnancy accompanied with higher incidence of obstetric complications,including preterm birth and preeclampsia specifically.

关 键 词：干燥综合征 妊娠 妊娠并发症 

分 类 号：R714.259[医药卫生—妇产科学]