糖尿病视网膜病变患者TGF-β1、TGF-β2水平及临床意义  

Levels and clinical significance of TGF-β1 and TGF-β2 in patients with diabetic retinopathy

作　　者：王娟[1] 储辉[2] WANG Juan;CHU Hui(Department of Ophthalmology,Branch Hospital of Huai’an First People’s Hospital,Jiangsu Province,Huai’an 223002,China;Department of Endocrinology,Branch Hospital of Huai’an First People’s Hospital,Jiangsu Province,Huai’an 223002,China)

机构地区：[1]江苏省淮安市第一人民医院分院眼科,江苏淮安223002 [2]江苏省淮安市第一人民医院分院内分泌科,江苏淮安223002

出　　处：《中国医药导报》2021年第18期123-126,共4页China Medical Herald

基　　金：江苏省卫生科研项目(YK2016004)。

摘　　要：目的探讨糖尿病视网膜病变(DR)患者血清转化生长因子(TGF)-β1、TGF-β2水平及临床意义。方法选取2015年1月—2018年5月在江苏省淮安市第一人民医院分院(以下简称“我院”)治疗的2型糖尿病患者189例,其中DR患者61例(DR组),非增值期糖尿病视网膜病变(NPDR)患者38例,增值期糖尿病视网膜病变(PDR)患者23例。无DR患者128例(NDR组)。同时选取我院同期健康体检者100名作为对照组。检测血清TGF-β1、TGF-β2、空腹血糖及糖化血红蛋白(HbA1c)水平。结果DR组血清TGF-β1、TGF-β2和HbA1c高于NDR组和对照组(P<0.05);空腹血糖高于对照组(P<0.05);PDR患者血清TGF-β1、TGF-β2和HbA1c高于NPDR患者(P<0.05);PDR和NPDR患者空腹血糖比较,差异无统计学意义(P>0.05);TGF-β1、TGF-β2与HbA1c呈正相关(r=0.347、0.457,P<0.05)。结论DR患者血清TGF-β1和TGF-β2明显升高,在疾病发生发展中可能有重要作用,且与HbA1c水平有一定正相关关系。Objective To investigate the serum levels of transforming growth factor(TGF)-β1 and TGF-β2 and their clinical significance in diabetic retinopathy(DR)patients.Methods A total of 189 patients with type 2 diabetes mellitus who were treated in Branch Hospital of Huai’an First People’s Hospital(“our hospital”for short)in January 2015 and May 2018 were selected,including 61 DR patients(DR group),38 non-value-added diabetic retinopathy(NPDR)and 23 value-added diabetic retinopathy(PDR).There were 128 patients without DR(NDR group).At the same time,100 health checkups from our hospital during the same period were selected as the control group.The levels of TGF-β1,TGF-β2,fasting blood glucose,and glycated hemoglobin(HbA1c)in serum were detected.Results Serum TGF-β1,TGF-β2 and HbA1c in DR group were higher than those in NDR group and control group(P<0.05).Fasting blood glucose was higher than that in control group(P<0.05).Serum TGF-β1,TGF-β2,and HbA1c in PDR patients were higher than those in NPDR patients(P<0.05).There was no significant difference in fasting blood glucose between PDR and NPDR patients(P>0.05).TGF-β1 and TGF-β2 were positively correlated with HbA1c(r=0.347,0.457,P<0.05).Conclusion Serum TGF-β1 and TGF-β2 are significantly increased in DR patients,which may play an important role in the occurrence and development of the disease,and have a positive correlation with HbA1c level.

关 键 词：糖尿病视网膜病变 转化生长因子Β 糖尿病 糖化血红蛋白 

分 类 号：R58[医药卫生—内分泌]