小鼠肝纤维化模型复制方法的研究进展  

Research progress of mice models for hepatic fibrosis

作　　者：王梓睿 田飞鸿 饶木艳 姚继红[1] 李华[1] 王丽[1] Zi-rui Wang;Fei-hong Tian;Mu-yan Rao;Ji-hong Yao;Hua Li;Li Wang(College of Pharmacy,Dalian Medical University,Dalian,Liaoning 116044,China)

机构地区：[1]大连医科大学药学院,辽宁大连116044

出　　处：《中国现代医学杂志》2021年第12期46-50,共5页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:81773799);辽宁省博士科研启动基金项目(No:20170520343)。

摘　　要：肝纤维化是肝损伤后修复反应的失衡,其发生机制尚未明确。复制与人类肝纤维化相似的动物模型是深入研究肝纤维化发病机制与药物治疗的重要基础。该文主要针对胆汁淤积、毒物诱导、代谢障碍、酒精损伤、免疫异常及血吸虫等致肝纤维化模型复制方法进行综述,以供肝纤维化研究者选择参考。Hepatic fibrosis is a disturbance of repair responses after liver injury,but the underlying mechanism is not clear.To establish the animal models which mirror human liver fibrosis is an important basis for further study of the pathogenesis and drug treatment of liver fibrosis.Thus,this review briefly summarizes current methods of establishing hepatic fibrosis models in mice,including the paradigms induced via cholestasis,toxic substances,metabolic disorders,alcohol administration,immune abnormalities and schistosomiasis,which can serve as a reference for further researches on hepatic fibrosis.

关 键 词：肝硬化 模型 动物 小鼠 

分 类 号：R657.31[医药卫生—外科学]