A recurrent mutation in TBPL2 causes diminished ovarian reserve and female infertility  

作　　者：Wen-Bin He Ya-Xin Zhang Chen Tan Lan-Lan Meng Gang Liu Yuan Li Fei Gong Bai-Lin Wu Guang-Xiu Lu Ge Lin Juan Du Yue-Qiu Tan 

机构地区：[1]Reproductive and Genetic Hospital of CITIC-Xiangya,Changsha 410083,China [2]Institute of Reproductive and Stem Cell Engineering,School of Basic Medical Science,Central South University,Changsha 410083,China [3]Clinical Research Center For Reproduction and Genetics In Hunan Province,Changsha 410083,China [4]Boston Children's Hospital and Harvard Medical School,Boston,USA

出　　处：《Journal of Genetics and Genomics》2020年第12期785-788,共4页遗传学报（英文版）

基　　金：This study was supported by grants from the National Key Research&Developmental Program of China(2018YFC1004901);National Natural Science Foundation of China(81771645 and 81971447);Hunan Provincial Natural Science Foundation of China(2019JJ51006);the Key Grant of Prevention and Treatment of Birth Defect from Hunan Province(2019SK1012);the Scientific Research Foundation of Reproductive and Genetic Hospital of CITIC-Xiangya grants(YNXM-201912).

摘　　要：Diminished ovarian reserve(DOR)is a disorder of ovarian function in which the ovary loses its normal reproductive potential,including decreasing oocyte quantity and quality.The disorder is associated with infertility in women of reproductive age with regular menses and poor response to controlled ovarian hyperstimulation(Broekmans et al.,2009).

关 键 词：INFERTILITY STIMULATION al. 

分 类 号：R711.6[医药卫生—妇产科学]