微波辐射下KF/nano-γ-Al_(2)O_(3)催化合成二硫代氨基甲酸酯类化合物  

Syntheses of Dithiocarbamates Catalyzed by KF/nano-γ-AlO under Microwave Irradiation

作　　者：陈赛赛 洪志 黄霄瑜 吕晓青 李宗阳 胡心柔 阮馨颖 俞倩妍 Chen Saisai;Hong Zhi;Huang Xiaoyu;Lv Xiaoqing;Li Zongyang;Hu Xinrou;Ruan Xinying;Yu Qianyan(School of Pharmaceutical and Materials Engineering,Taizhou University,Taizhou,318000)

机构地区：[1]台州学院医药化工与材料工程学院,台州318000

出　　处：《化学通报》2021年第6期596-603,共8页Chemistry

基　　金：浙江省基础公益研究计划项目资助。

摘　　要：本文报道以缺电子烯烃、胺类和二硫化碳为原料,以PEG-400为溶剂,在固体碱KF/nano-γ-Al_(2)O_(3)催化下,经微波辅助的Michael加成反应高效地合成二硫代氨基甲酸酯类化合物,收率为76.5%~91.6%。对催化剂、溶剂、微波功率、反应时间等影响因素进行了考察,确定了优化的反应条件。该方法具有反应时间短、收率高和环境友好等特点。另外,本文还报道了苯甲醛、酮类、胺类与二硫化碳四组分在PEG-400溶液中,在固体碱KF/nano-γ-Al_(2)O_(3)催化下,经微波辐射"一锅法"合成二硫代氨基甲酸酯类化合物的反应,收率为73.4%~82.8%。In this paper, an efficient method for the synthesis of dithiocarbamates under microwave irradiation condition with KF/nano-γ-Al_(2)O_(3) catalyzed Michael addition of electron-deficient alkenes, amines and carbon disulfide in the PEG-400 solution was developed with yields of 76.5% to 91.6%. Meanwhile, the effects of the catalyst, solvent, microwave power, reaction time on the reaction were investigated, and the optimum conditions of the experiment were determined. This method has the advantages of short reaction time, high yield and environmental friendliness. In addition, KF/nano-γ-Al_(2)O_(3) catalyzed one-pot synthesis of dithiocarbamates from benzaldehyde, ketones, amines and carbon disulfide in PEG-400 solution under microwave irradiation was investigated. The yields were 73.4%~82.8%.

关 键 词：二硫代氨基甲酸酯类 微波辐射 Michael加成 KF/nano-γ-Al_(2)O_(3) 

分 类 号：TQ225.24[化学工程—有机化工] TQ426