壳聚糖纳米纤维膜的制备与研究进展  

Research progress of chitosan nanofiber membrane preparing by electrospinning

作　　者：刘其海[1,2,3] 谢婉婷 贾振宇 朱小花[3] 王荣辉 Liu Qihai;Xie Wanting;Jia Zhenyu;Zhu Xiaohua;Wang Ronghui(College of Chemistry and Chemical Engineering,Zhongkai University of Agriculture and Engineering,Guangzhou 510225;Guangdong Weiqian Technology Co.,Ltd.,Foshan 528216;Zhanjiang Botai bio-chemical Technology Industrial Co.,Ltd.,Zhanjiang 524051)

机构地区：[1]仲恺农业工程学院化学化工学院,广州510225 [2]广东维芊科技有限公司,佛山528216 [3]湛江博泰生物化工科技实业有限公司,湛江524051

出　　处：《化工新型材料》2021年第5期214-216,221,共4页New Chemical Materials

基　　金：广东省省级科技计划项目(2016A010105022,2017A010103024);广州市科技计划项目(201704020023);广东省促进经济发展专项资金(粤自然资源合[2019]016号);湛江市海洋经济创新发展示范市建设项目(湛海创2017C4A);湛江市科技发展专项资金竞争性分配项目(2016A02010)。

摘　　要：壳聚糖(CS)是由甲壳素经过脱乙酰基(脱乙酰度55%以上)得到的产物,具有良好的生物相容性、生物可降解性和无细胞毒性,被广泛用于生物医药等领域。CS纳米纤维膜能够改善CS的水溶性,增大膜的比表面积及孔隙率等,有利于提高产品性能,是目前CS研究的新方向。利用静电纺丝制备CS纳米纤维是较为常用的方法之一,所得纳米纤维具有良好的生物相容性和生物降解性,且比表面积大大增加,孔隙率也有所提高。综述了静电纺丝制备CS纳米纤维膜的原理及应用领域。Chitosan is a product obtained by subjecting chitin to deacetylation(degree of deacetylation of 55%or more).It has good biocompatibility,biodegradability and no cytotoxicity,and widely used in biomedicine.The preparation of chitosan nanocomposite fiber membrane can improve the water solubility of chitosan,increase the specific surface area and porosity of the membrane,and improve the performance of the product which has been a new research direction of chitosan.Electrospinning is considered to be an effective technique for preparing polymer nanofibers.Preparation of chitosan nanofibers by electrospinning is one of the more commonly used methods.The obtained nanofibers have biocompatibility,biodegradability and specific surface area.Excellent characteristics such as large size and high porosity.The preparation principle of chitosan nanofibers by electrospinning and its application fields were reviewed.

关 键 词：静电纺丝 壳聚糖 纳米纤维膜 生物相容性 

分 类 号：TQ317[化学工程—高聚物工业]