Feasible Fabrication of Hollow Micro-vesicles by Non-amphiphilic Macromolecules Based on Interfacial Cononsolvency  

作　　者：Jing-Hong Wang Rui Chen Zi-Qing Zhao Jie Shen He Yang Yan Luo Gao-Jian Chen Hong Chen John L.Brash 

机构地区：[1]State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China [2]Center for Soft Condensed Matter Physics and Interdisciplinary Research&School of Physical Science and Technology,Soochow University,Suzhou 215006,China [3]Department of Chemical Engineering and School of Biomedical Engineering,McMaster University,Hamilton,Ontario,Canada

出　　处：《Chinese Journal of Polymer Science》2021年第7期856-864,共9页高分子科学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21905192,21935008 and 21674074);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)and China Postdoctoral Science Foundation(No.2019M661925).

摘　　要：Herein we present a new perspective showing that water-soluble liquids,when added to water,undergo transient emulsification before complete dissolution.Thus,non-amphiphilic macromolecules can self-assemble at the two-miscible-phase interface when cononsolvent effect appears.A representative case shown here is that when poly(A/-isopropylacrylamide)(PNIPAm),prepared by aqueous radical polymerization,in methanol solution is added into water,the polymer chains rapidly self-assemble into hollow micro-vesicles based on the cononsolvency at water/methanol interface.This finding provides a subtle strategy to prepare hollow micro-vesicles by non-amphiphilic polymers without template participating.We proposed a new concept^interfacial cononsolvencyw to describe the formation process.Due to the easy modification process,sugar-contained PNIPAm chains are synthesized by copolymerization.As an application example,it is shown that these sugar-contained PNIPAm chains can afford MsweetH micro-vesicles(containing glucose residues).And the"sweer"micro-vesicles can well mimick the protocells which are involved in the recognition of bacteria.

关 键 词：Non-amphiphilic Interfacial cononsolvency Two-miscible-phase interface Hollow micro-vesicles PROTOCELLS 

分 类 号：TQ317[化学工程—高聚物工业]