周期性发热-阿弗他口炎-咽炎-淋巴结炎综合征临床特征分析  

Clinical analysis of periodic fever,aphthous somatitis,pharyngitis,adenitis syndrome

作　　者：庞冲[1] 黄小兰[2] 赖建铭[3] 梁洁琼[1] 王雨农 林枫[1] 宋贝贝 谷庆隆[1] Pang Chong;Huang Xiaolan;Lai Jianming;Liang Jieqiong;Wang Yunong;Lin Feng;Song Beibei;Gu Qinglong(Department of Otolaryngology,Children's Hospital Affiliated to Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]首都儿科研究所附属儿童医院耳鼻喉科,北京100020 [2]首都儿科研究所附属儿童医院中心实验室,北京100020 [3]首都儿科研究所附属儿童医院风湿免疫科,北京100020

出　　处：《北京医学》2021年第4期308-311,共4页Beijing Medical Journal

摘　　要：目的探讨周期性发热-阿弗他口炎-咽炎-淋巴结炎(periodic fever,aphthous stomatitis,pharyngitis,adenitis,PFAPA)综合征患儿的临床特点。方法选取2017年12月至2019年8月首都儿科研究所附属儿童医院住院的PFAPA综合征患儿31例,收集其临床表现、家族史、既往史及相关辅助检查,包括血常规、CRP、肝肾功能、细胞免疫、体液免疫、心电图、腹部超声等进行分析。10例行扁桃体切除术,其余患儿保守治疗,观察治疗结果。结果PFAPA综合征患儿热峰为(39.93±0.64)℃,每次发热持续时间相差≤1 d,相对恒定,但不同患儿之间发作时长和间隔时间有差异,为3~7 d。其中10例行扁桃体切除术,术后WBC、CRP较术前明显下降[10.5(9.7,11.4)×10^(9)/L比6.7(5.5,8.3)×10^(9)/L,11.0(11.0,18.0)mg/L比1.0(1.0,2.0)mg/L],差异有统计学意义(P<0.01)。结论PFAPA综合征的临床特点主要有周期性发热、体温正常期外周血WBC、CRP水平增高等,扁桃体切除术对其治疗有效。Objective To investigate the clinical features of periodic fever,aphthous stomatitis,pharyngitis,adenitis(PFAPA)syndrome in children.Methods A total of 31 patients were enrolled in Children's Hospital Affiliated to Capital Institute of Pediatrics from December 2017 to August 2019.All the clinical data was collected,including routine blood test,CRP,function of liver and kidney,cellular immunity and humoral immunity,electrocardiogram,abdominal ultrasound,family history and past history.Tonsillectomy was performed on 10 children,and conservative treatment was performed on the other children.Results The fever peak was(39.93±0.64)℃and the difference of duration of fever was less than one day.However,the duration and interval of attacks varied from three to seven days.Ten patients underwent tonsillectomy and the peripheral blood WBC and CRP of the 10 cases group after operation were significantly lower than those before operation[10.5(9.7,11.4)×10^(9)/L vs.6.7(5.5,8.3)×10^(9)/L,11.0(11.0,18.0)mg/L vs.1.0(1.0,2.0)mg/L],the difference was statistically significant(P<0.01).Conclusions The clinical features of PFAPA syndrome include periodic fever,the increase levels of peripheral blood leukocyte count and CRP during normal temperature period.Tonsillectomy is effective in PFAPA syndrome children.

关 键 词：周期性发热-阿弗他口炎-咽炎-淋巴结炎综合征 周期性发热 诊断 

分 类 号：R725.9[医药卫生—儿科]