银杏内酯类成分治疗缺血性脑卒中药理作用机制的研究进展  

Research Progress on Pharmacological Mechanisms of Ginkgolides in the Treatment of Ischemic Stroke

作　　者：王刚 姚明江[2] 徐立[2] 曹姗 李秀芳 刘建勋[2] Wang Gang;Yao Mingjiang;Xu Li;Cao Shan;Li Xiufang;Liu Jianxun(Yunnan University of Chinese Medicine,Kunming 650500;Institute of Basic Medical Sciences,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Key Laboratory of Pharmacology of Chinese Materia Medica,Beijing 100091)

机构地区：[1]云南中医药大学,昆明650500 [2]中国中医科学院西苑医院基础医学研究所,中药药理北京市重点实验室,北京100091

出　　处：《中药药理与临床》2021年第2期216-220,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(编号:81873040、81873041)。

摘　　要：银杏内酯类成分是银杏叶中特有的活性成分,大量研究显示其具有神经保护和修复作用,包括维持血脑屏障功能、减轻脑水肿、改善能量代谢、抗氧化、抗炎、抗凋亡、减轻兴奋性氨基酸毒性、促血管新生和神经发生,能够针对缺血性脑卒中不同病理环节发挥治疗作用。因此,本文在检索近年来银杏内酯类成分相关文献的基础上,对上述药理作用及其作用机制进行系统的梳理和总结以期为进一步的开发和应用提供参考。Ginkgolides are unique active ingredients in Ginkgo biloba leaves. Substantial studies have shown that they have neuroprotective and repair effects, including maintaining the blood-brain barrier function, reducing brain edema, improving energy metabolism, anti-oxidation, anti-inflammation, anti-apoptosis, reducing excitatory amino acid toxicity, promoting angiogenesis and neurogenesis, they can also play a therapeutic role in different pathological stages of ischemic stroke. In this paper, based on the search of the literature related to ginkgolides in recent years, the above pharmacological effects and mechanisms were systematically described and summarized, in order to provide reference for further development and application.

关 键 词：银杏内酯 缺血性脑卒中 能量代谢 氧化应激 炎症 神经发生 

分 类 号：R285[医药卫生—中药学]