The baroreflex afferent pathway plays a critical role in H_(2)S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions  

作　　者：Ying Li Yan Feng Li Liu Xue Li Xin-yu Li Xun Sun Ke-xin Li Rong-rong Zha Hong-dan Wang Meng-di Zhang Xiong-xiong Fan Di Wu Yao Fan Hao-cheng Zhang Guo-fen Qiao Bai-yan Li 

机构地区：[1]Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China,Key Laboratory of Cardiovascular Medicine Research,Ministry of Education),College of Pharmacy,Harbin Medical University,Harbin 150081,China [2]Department of Pharmacy,PLA Rocket Force Characteristic Medical Center,Beijing 100088,China [3]Department of Biomedical Engineering,Indiana University–Purdue University,Indianapolis,IN 46202,USA [4]Department of Physics,School of Science,Indiana University–Purdue University,Indianapolis,IN 46202,USA

出　　处：《Acta Pharmacologica Sinica》2021年第6期898-908,共11页中国药理学报（英文版）

基　　金：This work was supported by research grants from the National Natural Science Foundation of China(31171122,81573431,and 81971326).

摘　　要：Hydrogen sulfide(H_(2)S),which is closely related to various cardiovascular disorders,lowers blood pressure(BP),but whether this action is mediated via the modification of baroreflex afferent function has not been elucidated.Therefore,the current study aimed to investigate the role of the baroreflex afferent pathway in H_(2)S-mediated autonomic control of BP regulation.The results showed that baroreflex sensitivity(BRS)was increased by acute intravenous NaHS(a H_(2)S donor)administration to renovascular hypertensive(RVH)and control rats.Molecular expression data also showed that the expression levels of critical enzymes related to H_(2)S were aberrantly downregulated in the nodose ganglion(NG)and nucleus tractus solitarius(NTS)in RVH rats.A clear reduction in BP by the microinjection of NaHS or L-cysteine into the NG was confirmed in both RVH and control rats,and a less dramatic effect was observed in model rats.Furthermore,the beneficial effects of NaHS administered by chronic intraperitoneal infusion on dysregulated systolic blood pressure(SBP),cardiac parameters,and BRS were verified in RVH rats.Moreover,the increase in BRS was attributed to activation and upregulation of the ATP-sensitive potassium(KATP)channels Kir6.2 and SUR1,which are functionally expressed in the NG and NTS.In summary,H_(2)S plays a crucial role in the autonomic control of BP regulation by improving baroreflex afferent function due at least in part to increased KATP channel expression in the baroreflex afferent pathway under physiological and hypertensive conditions.

关 键 词：hydrogen sulfide hydrogen sulfide synthase blood pressure regulation baroreflex afferent pathway potassium channel protein kinase 

分 类 号：R544.1[医药卫生—心血管疾病]