Adapt or perish:SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain  

作　　者：Marta Ribes Carlos Chaccour Gemma Moncunill 

机构地区：[1]ISGlobal,Hospital Clínic-Universitat de Barcelona,Barcelona,Spain [2]Ifakara Health Institute,Ifakara,United Republic of Tanzania [3]Facultad de Medicina,Universidad de Navarra,Pamplona,Spain

出　　处：《Signal Transduction and Targeted Therapy》2021年第5期1416-1417,共2页信号转导与靶向治疗（英文）

基　　金：M.R.and C.Ch.received salary support from Unitaid through the BOHEMIA grant to ISGlobal.ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the“Centro de Excelencia Severo Ochoa 2019-2023”Program(CEX2018-000806-S);support from the Generalitat de Catalunya through the CERCA Program.

摘　　要：In a recent report in Science,McCarthy et al.promptly observed a pattern of recurrent deletions in four discrete regions of the N-terminal Domain(NTD)of the Spike protein,which provide resistance to antibody neutralization,suggesting convergent evolution due to selective pressure and antigenic drift.

关 键 词：al. PROMPT Domain 

分 类 号：R373[医药卫生—病原生物学]